This CME-certified enduring activity is jointly provided by Albert Einstein College of Medicine and RedMedEd.
Support for this activity has been provided through an educational grant from Pfizer.
To optimize outcomes for patients with chronic myeloid leukemia (CML), early treatment with the most appropriate first-line tyrosine kinase inhibitor (TKI) is vital. The key to achieving an early and enduring molecular response is the selection of a TKI tailored to the patient’s disease and comorbidity profiles. Mutational resistance to first-generation TKI imatinib and treatment discontinuation because of side effects have spurred the recent development of second- and third-generation TKIs that display different potencies and side-effect profiles.
This Virtual Practice features hands-on modules that summarize the latest advances in TKI treatment; review the most effective methods for monitoring early response and long-term therapeutic outcomes; assess the treatment milestones and mutational analyses to identify when a change in TKI therapy is needed; compare toxicity profiles of the currently available TKI agents; and examine how toxicity could interact with a patient’s pre-existing comorbidities and influence adherence and outcomes.
This activity has been designed to meet the educational needs of hematologists, medical oncologists, health system pharmacists, oncology nurses, nurse practitioners, physician assistants, and other health care professionals involved in the care of patients with CML.
Upon completion of this activity, participants should be better able to:
Summarize recent treatment advances for CML and their potential implications for clinical practice
Explain current clinical evidence on treatment goals and monitoring steps for patients with chronic-phase CML receiving TKI therapy
Select treatment in the frontline setting based on current clinical evidence and disease- and patient-specific characteristics to maximize the likelihood of achieving complete molecular remission/cytogenetic remission
Recognize differences in the toxicity profile among TKIs and the impact of these differences in tailoring treatment for the individual patient
Conflict Of Interest Disclosure Policy
The Conflict of Interest Disclosure Policy of Albert Einstein College of Medicine requires that faculty participating in any CME activity disclose to the audience any relationship with a pharmaceutical or equipment company. *Any presenter whose disclosed relationships prove to create a conflict of interest with regard to their contribution to the activity will not be permitted to present.
Albert Einstein College of Medicine also requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.
*The ACCME defines a Commercial Interest as an entity producing, marketing, re-selling or distributing health care goods or services consumed by or used on, patients. The ACCME does not consider providers of clinical service directly to patients to be commercial interest.
Elias Jabbour, MD—Program Chair Associate Professor Department of Leukemia Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston, Texas
Dr. Jabbour has disclosed the following relevant financial relationships: Contracted Research: AbbVie, Amgen, Novartis, Pfizer, Takeda
Michael W. Deininger, MD, PhD Chief, Division of Hematology/Hematologic Malignancies Huntsman Cancer Institute M. M. Wintrobe Professor of Medicine Senior Director of Transdisciplinary Research University of Utah Salt Lake City, Utah
Dr. Deininger has disclosed the following relevant financial relationships: Advisory Board: Ariad, Blueprint, Galena Biopharma, Incyte, Novartis, Pfizer Consultant: Incyte, Novartis, Pfizer Contracted Research: Novartis, Pfizer
Jerald Patrick Radich, MD Member, Clinical Research Division Fred Hutch Professor of Medicine University of Washington Seattle, Washington
Dr. Patrick Radich has disclosed the following relevant financial relationships: Consultant: Adaptive, Amgen, Novartis, Seattle Genetics Contracted Research: Novartis
Accredited Provider Disclosures
Albert Einstein College of Medicine The staff of the Center for Continuing Medical Education of Albert Einstein College of Medicine have no conflict of interest with commercial interests related directly or indirectly to this educational activity.
CME Reviewer Victor B. Hatcher, PhD Associate Dean for CME Professor, Department of Biochemistry Professor, Department of Medicine Albert Einstein College of Medicine Montefiore Medical Center Bronx, New York
Dr. Hatcher has disclosed no relevant financial relationships.
Peer Reviewer Amit Verma, MBBS Professor, Department of Medicine (Oncology) Professor, Department of Developmental & Molecular Biology Albert Einstein College of Medicine Director, Division of Hematology-Oncology Montefiore Medical Center Bronx, New York
Dr. Verma has disclosed no relevant financial relationships.
RedMedEd Denise C. LaTemple, PhD, Director of Scientific Services, has disclosed no relevant financial relationships. Yvette Murley, PhD, Medical Director, has disclosed no relevant financial relationships. Kristen Petro Slade, Operations Director, has disclosed no relevant financial relationships. Jonathan S. Simmons, ELS, Senior Managing Editor, has disclosed no relevant financial relationships. Karen Smith, Creative Director, has disclosed no relevant financial relationships. Karen Tenaglia, Project Manager, has disclosed no relevant financial relationships.
AMA PRA Category 1 Credit(s)TM
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Albert Einstein College of Medicine and RedMedEd. Albert Einstein College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
Albert Einstein College of Medicine designates this enduring material for a maximum of 1.00 AMA PRA Category 1 CreditTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosure of Unlabled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Albert Einstein College of Medicine, Montefiore Medical Center, RedMedEd, and Pfizer do not recommend the use of any agent outside the labeled indications.
Dr. Jabbour discusses the unlabeled/investigational use of ponatinib for CML treatment.
The information presented in this activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician regarding diagnosis and treatment of a specific patient’s medical condition.
The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Albert Einstein College of Medicine, Montefiore Medical Center, RedMedEd, or Pfizer. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Clicking "START ACTIVITY" will send you away from myCME to our partner site, RedMedEd to complete the activity.
There are no fees to participate in the activity. Participants must review all activity information, including the learning objectives, disclosure statements, and content. To receive CME credit, participants must complete the posttest (achieving a grade of 80% or greater) and program evaluation. Certificates can be printed immediately and will not be stored in your myCME CME History.
For questions regarding CME credit, please contact Albert Einstein College of Medicine at (718) 920-6674 or firstname.lastname@example.org.
For technical questions related to this activity, please contact RedMedEd at (610) 251-6841 or email@example.com.
Apple iPad or iPad mini (iOS 8 or higher) with an Internet connection
A computer with an Internet connection
Internet browser: Google Chrome, Internet Explorer 9 or higher, Firefox 26 or higher, or Safari 5 or higher
Additional software: Adobe Flash Player and/or an HTML 5-capable browser is required for video or audio playback; Adobe Acrobat Reader may occasionally be required
Albert Einstein College of Medicine, and Montefiore Medical Center, Center for Continuing Medical Education (Einstein) protects the privacy of personal and other information regarding participants and educational collaborators. Einstein will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting to the ACCME.
Einstein maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse, or alteration of information collected from you.