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Severe Asthma: Clinical Phenotypes and the Emerging Age of Personalized Therapy

Severe Asthma: Clinical Phenotypes and the Emerging Age of Personalized Therapy


Patient Case Simulations

Time to Complete

1.5 hours


June 30, 2017


August 31, 2018
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Maximum Credits

1.50 / AMA PRA Category 1 CreditsTM

Content update: 12/21/17

Accredited Provider

This CME-certified enduring activity is jointly provided by

Commercial Supporter

Support for this activity has been provided through an educational grant from AstraZeneca.

Program Description

The FDA’s approval of several new tailored biologic therapies offers promise to a subset of patients with severe asthma, though identifying the asthma phenotypes (ie, eosinophilic and noneosinophilic) for which these new agents are most appropriate remains a key factor of their successful use.

This CME e-learning Virtual Practice activity provides three modules that discuss the effective use of the newest biologic drugs and address key aspects of successfully assessing and treating patients with severe asthma.

To complete the Virtual Practice, review all content in the Exam Rooms and the Main Conference Room; each room (module) confronts you with challenging clinical scenarios involving patients with severe asthma, similar to those you are likely to encounter in your own practice.

  • Main Conference Room (Clinical Callout): Here you’ll find four patient vignettes that end at a critical clinical decision point. Your challenge: assess the symptoms, risk factors, and medical histories and choose the most appropriate next step from several possible clinical strategies. But be careful: only one option reflects current best practice!
  • Exam Room 1: Margaret Thomas, 40, has had asthma for 10 years, but her symptoms have worsened recently and she has experienced two serious exacerbations. Was it a change in her medications? Is it related to her allergies?
  • Exam Room 2: Al Carter, 55, was first diagnosed with asthma 15 years ago. In the last 3 months, his asthma has been uncontrolled despite the use of oral corticosteroids, and he was hospitalized. Are adjustments needed to Al’s regimen? If so, what are they?
  • Resource Library: Offers downloadable content discussed in the Virtual Practice.

Intended Audience

This activity has been designed to meet the educational needs of allergists, immunologists, pulmonologists, and primary care providers—including nurse practitioners and physician assistants—who are involved in the treatment of patients with severe asthma.

Educational Objectives

Upon completion of this activity, participants should be able to:

  • Discuss the two main types of severe asthma and the treatment implications of each
  • Discuss the most recent Global Initiative for Asthma (GINA) guidelines for severe asthma treatment (Steps 4/5)
  • Outline a personalized treatment plan, using targeted biologic therapies, to achieve and maintain control for patients with severe asthma based on underlying phenotype
  • Demonstrate how incorporating patient education and communication strategies can improve medication adherence and asthma control

Conflict Of Interest Disclosure Policy

According to the disclosure policy of RBHS and to conform with Joint Accreditation requirements and FDA guidelines, individuals who are in a position to control the content of this educational activity are required to disclose to activity participants the existence of any relevant relationships with any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients, with the exemption of nonprofit or government organizations and non-health care related companies, within the past 12 months. The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.


Bradley E. Chipps, MD (Program Chair)
Medical Director
Capital Allergy & Respiratory Disease Center
Sacramento, CA

Dr. Chipps has disclosed the following relevant financial relationships:
Consultant, Speakers Bureau, and Scientific Advisory Board: AstraZeneca, Boehringer Ingelheim, Circassia, Genentech, Novartis Pharmaceuticals, Teva Pharmaceutical Industries

Stephen P. Peters, MD, PhD
Thomas H. Davis Chair in Pulmonary Medicine
Chief, Section on Pulmonary, Critical Care, Allergy & Immunologic Diseases
Professor of Internal Medicine, Pediatrics, and Translational Science
Wake Forest School of Medicine
Executive Director, Respiratory Service Line, Wake Forest Baptist Health
Winston-Salem, NC

Dr. Peters has disclosed the following relevant financial relationships:
Advisory Boards: Array Biopharma, AstraZeneca, Aerocrine, Airsonett AB, Boehringer Ingelheim, Experts in Asthma, Gilead Sciences, GlaxoSmithKline, Merck, Novartis Pharmaceuticals, Ono Pharmaceuticals, Pfizer, PPD Development, Quintiles, Regeneron Pharmaceuticals, Saatchi & Saatichi, Sanofi, Sunovion Pharmaceuticals, Targacept, Teva Pharmaceutical Industries, Theron Teva Pharmaceutical
Basic and Clinical Research: National Heart, Lung, and Blood Institute (Asthma Clinical Research Network, AsthmaNet, Severe Asthma Research Program, SubPopulations and InteRmediate Outcome Measures In COPD Study)
Pharmaceutical Trials: Actelion Pharmaceuticals, Amgen, AstraZeneca, Boehringer Ingelheim, Centocor, Cephalon, Genentech, GlaxoSmithKline, Forest Laboratories, MedImmune, Sanofi
Speakers Bureau: Integrity CE

Michael E. Wechsler, MD, MMSc
Cohen Family Asthma Institute
Professor of Medicine
Division of Pulmonary, Critical Care and Sleep Medicine
National Jewish Health
Denver, CO

Dr. Wechsler has disclosed the following relevant financial relationships:
Consultant: AstraZeneca, Boehringer Ingelheim, Boston Scientific, GlaxoSmithKline, Novartis Pharmaceuticals, Regeneron Pharmaceuticals, Sanofi, Teva Pharmaceutical Industries, Vectura Group
Grant/Research Support: GlaxoSmithKline, Sanofi

Accredited Provider Disclosures

Andrew Berman, MD, has disclosed no relevant financial relationships.

Field Testers
Peter Rattner, DO, and Jennifer Williams, MD, have disclosed no relevant financial relationships.

Rutgers Biomedical and Health Sciences Center for Continuing Outreach and Education
Patrick Dwyer, Director, Continuing Medical Education, has disclosed no relevant financial relationships.

Denise C. LaTemple, PhD, Director of Scientific Services, has disclosed no relevant financial relationships.
Jonathan S. Simmons, ELS, Senior Managing Editor, has disclosed no relevant financial relationships.
Karen Smith, Creative Director, has disclosed no relevant financial relationships.
Karen Tenaglia, Project Manager, has disclosed no relevant financial relationships.
Barbara Zosh, Director of Operations, has disclosed on relevant financial relationships.




AMA PRA Category 1 Credit(s)TM

Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by Rutgers Biomedical and Health Sciences and RedMedEd. Rutgers Biomedical and Health Sciences is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the health care team.

Designation Statement

Rutgers Biomedical and Health Sciences designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM .  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Advanced Practice Nurses, Nurses, Physician Assistants
Advanced practice nurses, nurses, and physician assistants may participate in this educational activity and earn a letter of attendance as AANP, ANCC, and AAPA accept AMA PRA Category 1 CreditsTM  through their reciprocity agreements.

Peer Review

To help ensure content objectivity, independence, and fair balance, and to ensure that the content is aligned with the interest of the public, Rutgers Biomedical and Health Sciences (RBHS) has resolved all potential and real conflicts of interest through content review by a non-conflicted, qualified reviewer. This activity was peer-reviewed for relevance, accuracy of content, and balance of presentation by:

Andrew Berman, MD, Professor of Medicine, Director, Division of Pulmonary and Critical Care Medicine/Allergy and Immunologic Diseases, Rutgers New Jersey Medical School, Newark, New Jersey.

This activity was pilot-tested for time required for participation by Peter Rattner, DO and Jennifer Williams, MD.

Disclosure of Unlabled Use

This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. RBHS and RedMedEd do not recommend the use of any agent outside the labeled indications.


The information presented in this activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician regarding diagnosis and treatment of a specific patient’s medical condition.

The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of any manufacturer of pharmaceuticals or devices, Rutgers Biomedical and Health Sciences, or RedMedEd. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Clicking "START ACTIVITY" will send you away from myCME to our partner site, RedMedEd. Full accreditation/designation and disclosure information will be provided on the RedMedEd site.

There are no fees to participate in the activity. Participants must review all activity information, including the learning objectives, disclosure statements, and content. To receive CME credit for participation, participants must complete the post-tests (achieving a passing grade of 80% or greater) and program evaluation. Certificates can be printed immediately and will not be stored in your myCME CME History.

For technical questions related to this activity, please contact RedMedEd at (610) 251-6841 or

For questions regarding the activity content, or CME-related questions or concerns, contact RBHS at (973) 972-4267 or

Hardware/Software Requirements

  • Apple iPad or iPad mini (iOS 8 or higher) with an Internet connection
  • A computer with an Internet connection
    • Internet browser: Google Chrome, Internet Explorer 9 or higher, Firefox 26 or higher, or Safari 5 or higher
    • Additional software: Adobe Flash Player and/or an HTML 5-capable browser is required for video or audio playback; Adobe Acrobat Reader may occasionally be required

Privacy Policy

This website is managed by RedMedEd, and RedMedEd’s printed privacy policy applies to this site. CME credit for this activity is provided by RBHS. If you register for CME credit for this educational activity, RedMedEd will forward relevant personally identifiable information to RBHS so that records can be maintained concerning any credits issued to you. Aggregated data concerning registrations, posttests, and evaluations may be shared, but RedMedEd will not knowingly share any personally identifiable information. RBHS may use the information you provide on this site to contact you about your CME credit or other relevant educational activities provided through RBHS. To review RBHS’ CE privacy policy, click here.

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© 2017. This CME certified activity is held as copyrighted by Rutgers Biomedical and Health Sciences and RedMedEd. All rights reserved including translation into other languages. No part of this activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval systems, without permission in writing from RBHS or RedMedEd.
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