WHO Offers Evidence-Based Folate Concentration Guidelines

Share this content:
WHO Offers Evidence-Based Folate Concentration Guidelines
WHO Offers Evidence-Based Folate Concentration Guidelines

WEDNESDAY, April 29, 2015 (HealthDay News) -- Evidence-based folate concentration guidelines for the prevention of neural tube defects (NTDs) have been developed by the World Health Organization (WHO), according to a report published in the April 24 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Amy M. Cordero, M.P.A., from the CDC in Atlanta, and colleagues developed evidence-based guidelines on the optimal blood folate concentrations in women of reproductive age for NTD prevention. Data were included from two studies that examined the correlation between red blood cell (RBC) and folate concentrations during pregnancy and NTD risk.

According to the WHO recommendations, in order to achieve the greatest reduction of NTDs, RBC folate concentrations should be >400 ng/mL in women of reproductive age. The RBC folate threshold of >400 ng/mL can be used as an indicator of folate insufficiency, but this threshold cannot predict the individual risk of having a NTD-affected pregnancy. For women of reproductive age, no serum folate threshold is recommended for prevention of NTDs at the population level. To obtain comparable results for RBC folate concentration across countries, microbiological assay is recommended as the most reliable choice.

"This approach can identify populations at increased risk for insufficient concentrations and allow for determination of appropriate nutritional interventions based on blood folate status and nutritional patterns of the target population to reach those most in need," the authors write.

Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Zika, West Nile Cases Reported in Alabama

Zika, West Nile Cases Reported in Alabama

State health officials note that Zika hasn't been transmitted locally

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Increased suicide risk with one, two, and three or more medical contacts for traumatic brain injury

Triple Combo Blood Pressure Pill Can Improve BP Control

Triple Combo Blood Pressure Pill Can Improve BP ...

Proportion achieving target BP increased with use of triple combo pill versus usual care at six months

is free, fast, and customized just for you!




Already a member?

Sign In Now »