Vitamin E, Selenium Don't Prevent Dementia in Older Men

Share this content:
Vitamin E, Selenium Don't Prevent Dementia in Older Men
Vitamin E, Selenium Don't Prevent Dementia in Older Men

WEDNESDAY, March 22, 2017 (HealthDay News) -- Neither vitamin E, selenium, nor the combination prevents dementia in asymptomatic older men, according to a study published online March 20 in JAMA Neurology.

Richard J. Kryscio, Ph.D., from the University of Kentucky in Lexington, and colleagues examined whether antioxidant supplements used alone or in combination could prevent dementia in asymptomatic older men. A total of 7,540 older men were recruited into the Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADViSE) randomized clinical trial; 3,786 of these men continued into a cohort study. Participants were randomized to vitamin E, selenium, vitamin E and selenium, or placebo, and were assessed for dementia while taking study supplements.

The researchers found that the incidence of dementia (4.4 percent) was not different among the four study arms. Compared with placebo, the hazard ratios were 0.88 (95 percent confidence interval, 0.64 to 1.20) for vitamin E, 0.83 (95 percent confidence interval, 0.60 to 1.13) for selenium, and 1.00 (95 percent confidence interval, 0.75 to 1.35) for the combination, after adjustment for participant demographic information and baseline self-reported comorbidities.

"Neither supplement prevented dementia," the authors write. "To our knowledge, this is the first study to investigate the long-term association of antioxidant supplement use and dementia incidence among asymptomatic men."

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text
Editorial

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ground Beef Recalled After E. Coli Outbreak

Ground Beef Recalled After <i>E. Coli</i> Outbreak

Beef was produced and packaged at Cargill Meat Solutions in Fort Morgan, Colo.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060

Long-Term Outcomes of Breast Implants Explored

Long-Term Outcomes of Breast Implants Explored

Higher rates of Sjogren syndrome, scleroderma, RA, stillbirth, melanoma for silicone implants

is free, fast, and customized just for you!




Already a member?

Sign In Now »