Vitamin D3 Improves Arterial Stiffness in Dose-Response Way

Share this content:
Vitamin D<sub>3</sub> Improves Arterial Stiffness in Dose-Response Way
Vitamin D3 Improves Arterial Stiffness in Dose-Response Way

WEDNESDAY, Jan. 10, 2018 (HealthDay News) -- For overweight African-Americans with vitamin D deficiency, arterial stiffness is improved by vitamin D3 supplementation in a dose-response manner, according to a study published online Dec. 7 in PLOS ONE.

Anas Raed, M.D., from Augusta University in Georgia, and colleagues examined the dose-response effects of vitamin D3 supplementation on arterial stiffness in 70 overweight African-Americans with serum 25-hydroxyvitamin D (25[OH]D) levels ≤20 ng/mL. Participants were randomized to monthly supplementation of 18,000 IU (~600 IU/day), 60,000 IU (~2,000 IU/day), or 120,000 IU (~4,000 IU/day) of vitamin D3 or placebo for 16 weeks (17, 18, 18, and 17 participants, respectively).

The researchers observed a dose-response increase in serum 25(OH)D concentrations between the groups with vitamin D3 supplementation. For carotid-femoral pulse wave velocity (PWV), there was a significant downward linear trend, with mean changes in carotid-femoral PWV of 0.13 m/s for placebo, and 0.02, −0.11, and −0.70 m/s for the 600, 2,000, and 4,000 IU/day groups, respectively. For carotid-radial PWV, the findings were similar, with mean changes of 0.24 m/s for placebo, and 0.09, −0.57, and −0.61 m/s for the 600, 2,000, and 4,000 IU/day groups, respectively.

"Arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner in overweight African-Americans with vitamin D deficiency," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Total Diabetes at 14 Percent in U.S. Adults for 2013-2016

Total Diabetes at 14 Percent in U.S. Adults ...

Prevalence of diagnosed and undiagnosed diabetes 9.7 and 4.3 percent; prevalence increased with age

Novel Immunotherapy May Up Survival in Melanoma Brain Mets

Novel Immunotherapy May Up Survival in Melanoma Brain ...

Findings in patients receiving checkpoint blockade immunotherapy for melanoma brain metastases

Positive Link Between Air Pollution, Diagnosis of Dementia

Positive Link Between Air Pollution, Diagnosis of Dementia

In multipollutant models, only nitrogen dioxide, PM2.5 remained significant

is free, fast, and customized just for you!




Already a member?

Sign In Now »