Usual Apixaban Dosing OK With One Dose-Reduction Criterion

This article originally appeared here.
Share this content:
Usual Apixaban Dosing OK With One Dose-Reduction Criterion
Usual Apixaban Dosing OK With One Dose-Reduction Criterion

FRIDAY, July 29, 2016 (HealthDay News) -- For patients in the Apixaban for Reduction of Stroke and Other Thromboembolic Complications in Atrial Fibrillation (ARISTOTLE) trial, the 5 mg twice daily dose of apixaban is beneficial and appropriate for those with one dose-reduction criterion, according to a study published online July 27 in JAMA Cardiology.

John H. Alexander, M.D., from the Duke Clinical Research Institute in Durham, N.C., and colleagues analyzed data on 17,322 participants from the ARISTOTLE trial. Of patients with one or no dose-reduction criteria assigned to receive the 5 mg twice daily dose of apixaban or warfarin, 3,966 had one dose-reduction criterion.

The researchers found that patients with one dose-reduction criterion had higher rates of stroke or systemic embolism and major bleeding compared to those with no dose-reduction criteria. Similar benefits were seen for 5 mg twice daily apixaban versus warfarin on stroke or systemic embolism among patients with one (hazard ratio [HR], 0.94; 95 percent confidence interval [CI], 0.66 to 1.32) or no dose-reduction (HR, 0.77; 95 percent CI, 0.62 to 0.97) criterion (P for interaction = 0.36). Benefits were also similar for major bleeding (HRs, 0.68 [95 percent CI, 0.53 to 0.87] and 0.72 [95 percent CI, 0.60 to 0.86], respectively) (P for interaction = 0.71). Patterns were similar for each dose-reduction criterion and across the spectrum of age, body weight, and creatinine level and clearance.

"Patients with atrial fibrillation and isolated advanced age, low body weight, or renal dysfunction have a higher risk of stroke or systemic embolism and major bleeding but show consistent benefits with the 5 mg twice daily dose of apixaban versus warfarin compared with patients without these characteristics," the authors write. "The 5 mg twice daily dose of apixaban is safe, efficacious, and appropriate for patients with only one dose-reduction criterion."

Several authors disclosed financial ties to pharmaceutical companies, including Bristol-Myers Squibb and Pfizer, which manufacture apixaban and funded the study.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Study Provides Estimates of U.S. Prevalence of Type 1, 2 Diabetes

Study Provides Estimates of U.S. Prevalence of Type ...

Prevalence of type 1 diabetes 0.5 percent, type 2 diabetes 8.5 percent among U.S. adults

Black Individuals at Highest Risk of Legal Intervention Injury

Black Individuals at Highest Risk of Legal Intervention ...

Increase in rates of injuries from 2005 to 2009, followed by a drop to 2015, returning to ~2005 levels

Research Links Doctor Burnout to Patient Safety Incidents

Research Links Doctor Burnout to Patient Safety Incidents

Physician burnout linked to increased risk of patient safety incidents, reduced patient satisfaction

is free, fast, and customized just for you!




Already a member?

Sign In Now »