USPSTF Says Screen Women With Higher Risk for BRCA Mutations

Share this content:
USPSTF Says Screen Women With Higher Risk for <i>BRCA</i> Mutations
USPSTF Says Screen Women With Higher Risk for BRCA Mutations

TUESDAY, Feb. 19, 2019 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends screening for women at increased risk for carrying a BRCA1/2 mutation as well as genetic counseling and testing as indicated for those screening positive. These recommendations form the basis of a draft recommendation statement published online Feb. 19 by the USPSTF.

Heidi D. Nelson, M.D., M.P.H., from the Oregon Health & Science University in Portland, and colleagues updated the 2013 USPSTF review on the benefits and harms of risk assessment, genetic counseling, and genetic testing for BRCA1/2-related cancer in women.

Using BRCA1/2 mutation testing or clinical risk criteria as reference standards, the researchers found familial risk models have moderate-to-high accuracy for guiding referrals to genetic counseling. Genetic counseling can reduce breast cancer worry, anxiety, and depression and increase understanding of risk. Based on these findings, the USPSTF recommends screening for women who have family members with breast, ovarian, tubal, or peritoneal cancer or women with an ethnicity or ancestry associated with BRCA1/2 gene mutations. Genetic counseling and, if indicated, genetic testing should be provided to women with positive screening results (B recommendation). Women whose family or personal history or ethnicity or ancestry is not associated with an increased risk for potentially harmful mutations in BRCA1/2 genes should not undergo routine screening, genetic counseling, or genetic testing (D recommendation).

The draft recommendation statement and evidence review are available for public comment from Feb. 19 to March 18, 2019.

Draft Evidence Review
Draft Recommendation Statement
Comment on Recommendation

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »