Use of Systematic Reviews Affects Newborn Screening Policy

Share this content:
Use of Systematic Reviews Affects Newborn Screening Policy
Use of Systematic Reviews Affects Newborn Screening Policy

TUESDAY, May 15, 2018 (HealthDay News) -- Use of systematic review methodology is associated with reduced likelihood of screening for rare diseases using the newborn blood spot test being recommended, according to a meta-analysis published online May 9 in The BMJ.

Sian Taylor-Phillips, Ph.D., from the University of Warwick in the United Kingdom, and colleagues conducted a systematic review and meta-analysis to examine the odds of recommending screening according to the use of systematic review methods across conditions. A total of 93 reports that assessed 104 conditions across 14 countries were included, totaling 276 recommendations.

The researchers found that screening was favored, not favored, and not recommended either way in 58, 36, and 7 percent of recommendations, respectively. A systematic review was included in only 22 percent of the recommendations. The probability of screening being recommended was reduced with use of a systematic review (38 versus 63 percent; odds ratio, 0.17). Evidence for test accuracy, benefits of early detection, and overdiagnosis was not considered in 42, 30, and 76 percent of the recommendations, respectively.

"Using systematic review methods is associated with a reduced probability of screening being recommended," the authors write. "Many national policy reviews of screening for rare conditions using the newborn blood spot test do not assess the evidence on the key benefits and harms of screening."

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

WPSI Recommends Annual Urinary Incontinence Screening

WPSI Recommends Annual Urinary Incontinence Screening

Due to limited evidence, other experts urge caution in implementing guideline for women

Young, Growing Athletes at High Risk for ACL Injuries

Young, Growing Athletes at High Risk for ACL ...

Athletic teams should provide program that includes muscle strengthening, proper technique training

Side Effects of Biologics for Rheumatic Dz May Up Anxiety

Side Effects of Biologics for Rheumatic Dz May ...

Common patient concerns are risks of cancer and tuberculosis activation

is free, fast, and customized just for you!




Already a member?

Sign In Now »