Two Cases of SCC Described After Ingenol Mebutate Gel Application

This article originally appeared here.
Share this content:
Two Cases of SCC Described After Ingenol Mebutate Gel Application
Two Cases of SCC Described After Ingenol Mebutate Gel Application

(HealthDay News) -- Two cases of squamous cell carcinoma (SCC) have been described, with rapid onset after application of ingenol mebutate gel for treatment of actinic keratosis (AK). The report was published online July 31 in the British Journal of Dermatology.

Juan Antonio Moreno Romero, M.D., from the Quirónsalud Hospital General de Catalunya in Barcelona, Spain, and colleagues describe two cases of SCC with rapid onset after ingenol mebutate gel application for the treatment of AKs.

The first case involved a 95-year-old woman who presented with an erythematous, flat, rough lesion on the forehead. She was treated for a clinical diagnosis of AK with 0.015 percent ingenol mebutate for three days. Four weeks later, a painful tumor had developed over the previous lesion; tumoral growth started in the first two weeks after treatment. A 15-mm crateriform nodule with a keratotic core was observed. The second case was a 78-year-old woman who consulted for multiple AKs on the neck base. She was prescribed 0.015 percent ingenol mebutate gel. The patient presented with an ulcerated tumor of about 14 mm diameter in the same anatomical location five weeks later. Tumoral growth started about two weeks after treatment application. After surgical excision, histological examination revealed a well-differentiated SCC.

"We believe that dermatologists should be alert to the possible emergence of new cases of SCCs after treatment with ingenol mebutate," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves First Generic EpiPen

FDA Approves First Generic EpiPen

Approval will address both rising costs and shortages of epinephrine

Report Details Corneal Infection Tied to Sleeping in Contacts

Report Details Corneal Infection Tied to Sleeping in ...

Six patients reported sleeping in lenses on regular basis; most had vision loss, permanent damage

Honey May Protect Children Who Swallow Button Batteries

Honey May Protect Children Who Swallow Button Batteries

Honey and Carafate appear to rapidly protect against batteries' caustic effects

is free, fast, and customized just for you!




Already a member?

Sign In Now »