Toxic Skin Effects Common With EGFR-TKI Use in NSCLC

Share this content:
Toxic Skin Effects Common With EGFR-TKI Use in NSCLC
Toxic Skin Effects Common With EGFR-TKI Use in NSCLC

FRIDAY, Dec. 11, 2015 (HealthDay News) -- For patients with non-small-cell lung cancer, treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is associated with skin toxic effects, according to a research letter study published online Dec. 10 in JAMA Dermatology.

Kai-Lung Chen, M.D., from the National Taiwan University Hospital in Taipei, and colleagues conducted a retrospective study to compare the incidences and severities of the four types of skin toxic effects for three different EGFR-TKIs. Data were included for 146 patients with non-small-cell lung cancer meeting the inclusion criteria; of these, 61, 117, and 93 had ever received gefitinib, erlotinib, and afatinib, respectively.

The researchers found that the incidence of acneiform eruption was highest, followed by pruritus and xerosis (67.2 to 76.3 percent and 47.5 to 63.4 percent, respectively). Paronychia incidence was the lowest and varied significantly among the EGFR-TKIs: 9.8, 12.8, and 39.8 for gefitinib, erlotinib, and afatinib, respectively (P < 0.001). For patients with treatment courses extending at least 180 days, afatinib therapy correlated with earlier paronychia onset and with more dermatologic visits within the first 180 days for any skin toxic effects.

"Aggressive dermatologic care for patients receiving EGFR-TKIs should be mandatory," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »