Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure

This article originally appeared here.
Share this content:
Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure
Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure

WEDNESDAY, March 30, 2016 (HealthDay News) -- For patients with rheumatoid arthritis (RA) and a first non-tumor necrosis factor inhibitor (TNFi) failure, treatment with tocilizumab seems more efficacious than abatacept or rituximab, according to a study published online March 27 in the International Journal of Rheumatic Diseases.

Tristan Pascart, M.D., from Lille University in Lomme, France, and colleagues conducted a retrospective, multicenter study involving patients treated for RA with abatacept, rituximab, or tocilizumab after a non-TNFi failure. Data were collected for 100 patients who started a second non-TNFi between 2006 and 2013 (15 treated with rituximab, 36 with tocilizumab, and 49 with abatacept).

The researchers found that the change in Disease Activity Index of 28 joints-erythrocyte sedimentation rate (DAS28-ESR) differed significantly between the groups (P = 0.001). The decrease in DAS28-ESR was higher for patients treated with tocilizumab versus abatacept (median, 36 versus 0 percent; P = 0.002). A similar difference was seen for tocilizumab and rituximab, although the difference was not significant (median decrease, 36 versus 0 percent; P = 0.07). The results were similar for 12-month change in DAS28-C-reactive protein.

"This study suggests a better efficacy of tocilizumab compared with abatacept and rituximab in situations of non-TNFi failure," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical technology industries.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wildfire Smoke Causing Poor Air Quality in U.S. Pacific Northwest

Wildfire Smoke Causing Poor Air Quality in U.S. ...

Air pollution advisories, air quality alerts issued for Washington, Oregon

Odds of Death Up With Exposure to Pregabalin, Opioids

Odds of Death Up With Exposure to Pregabalin, ...

Dose-response association with highest odds of opioid-related death with high-dose pregabalin

NYU Becomes First Medical School to Cover All Tuition

NYU Becomes First Medical School to Cover All ...

Full-tuition scholarships, regardless of need, offered to all new and current medical students

is free, fast, and customized just for you!




Already a member?

Sign In Now »