Three Novel Loci Associated With Polycystic Ovary Syndrome ID'd

Share this content:
Three Novel Loci Associated With Polycystic Ovary Syndrome ID'd
Three Novel Loci Associated With Polycystic Ovary Syndrome ID'd

MONDAY, Dec. 31, 2018 (HealthDay News) -- Three novel loci have been identified for polycystic ovary syndrome (PCOS), according to research published online Dec. 19 in PLOS Genetics.

Felix Day, Ph.D., from the University of Cambridge School of Clinical Medicine in the United Kingdom, and colleagues performed a meta-analysis of 10,074 PCOS cases and 103,164 controls of European ancestry and characterized PCOS-related traits.

The researchers identified three novel loci and replicated 11 previously identified loci. The genetic architecture was similar for PCOS diagnosed by self-report and for PCOS diagnosed by National Institutes of Health (NIH) or non-NIH Rotterdam criteria across common variants at 13 loci; only one locus differed significantly in its correlation by diagnostic criteria. In affected women, identified variants correlated with hyperandrogenism, gonadotropin regulation, and testosterone levels. There were genetic correlations with obesity, fasting insulin, type 2 diabetes, lipid levels, and coronary artery disease, indicating shared genetic architecture between PCOS and metabolic traits in linkage disequilibrium score regression analysis. Variants associated with body mass index, fasting insulin, menopause timing, depression, and male-pattern balding were suggested to play a causal role in PCOS in Mendelian randomization analyses.

"The genetic underpinnings of PCOS implicate neuroendocrine, metabolic, and reproductive pathways in the pathogenesis of disease," the authors write. "Our findings demonstrate the extensive power of genetic and genomic approaches to elucidate the pathophysiology of PCOS."

Several authors are employees of 23andMe.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wait Times Have Improved in VA Health Care System

Wait Times Have Improved in VA Health Care ...

Wait times similar to private sector in 2014 but shorter overall and in some specialties in 2017

Medication Treatment for Substance Abuse Up in Facilities

Medication Treatment for Substance Abuse Up in Facilities

2007 to 2016 saw increase in use of medication treatment, reaching 36.1 percent in 2016

Mindfulness, Stress Linked to Menopausal Symptoms

Mindfulness, Stress Linked to Menopausal Symptoms

Link between mindfulness and symptoms more robust in women experiencing higher stress

is free, fast, and customized just for you!




Already a member?

Sign In Now »