Thalidomide May Cause Epidermal Necrolysis in Multiple Myeloma

Share this content:
Thalidomide May Cause Epidermal Necrolysis in Multiple Myeloma
Thalidomide May Cause Epidermal Necrolysis in Multiple Myeloma

FRIDAY, Nov. 4, 2016 (HealthDay News) -- In patients with multiple myeloma, thalidomide may cause toxic epidermal necrolysis (TEN), according to a case report published online Nov. 2 in the International Journal of Dermatology.

Sewon Hwang, M.D., from Yeouido St. Mary's Hospital in Seoul, South Korea, and colleagues report on a case of TEN in a 62-year-old woman with multiple myeloma who was treated with thalidomide and dexamethasone. The patient developed fever and dysphagia, as well as irregularly shaped erythematous macules and patches on her face and trunk about four weeks after initiation of treatment. The lesions spread to her entire body; some evolved to flaccid blisters, and there was a positive Nikolsky's sign in the erythematous zone.

The authors note that elevations in erythrocyte sedimentation rate, C-reactive protein levels, and liver enzymes were seen in laboratory results, as well as an increased percentage of eosinophils. Full-thickness epidermal necrosis and subepidermal detachment were seen in skin biopsy from the trunk, with infiltration of lymphocytes and a few eosinophils in the papillary dermis. The patient was diagnosed with TEN and thalidomide was discontinued immediately. The patient was treated with prednisolone along with fluid replacement and wound dressing. After two weeks of intensive therapy the skin lesions resolved.

"In conclusion, dermatologists should keep in mind the possibility that thalidomide may cause TEN," the authors write. "Greater caution is required in patients receiving combination therapy with thalidomide and dexamethasone for the treatment of newly diagnosed multiple myeloma."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Gender Nonconformity Linked to Students' Mental Distress

Gender Nonconformity Linked to Students' Mental Distress

For male students, gender nonconformity strongly associated with substance use

Participation Up With Online Diabetes Prevention Program

Participation Up With Online Diabetes Prevention Program

But weight loss no different for online, in-person DPP for obese/overweight veterans with prediabetes

Net Benefit of Anticoagulants for A-Fib Varies With Stroke Rate

Net Benefit of Anticoagulants for A-Fib Varies With ...

Benefit of warfarin anticoagulation varies with varying published stroke rates

is free, fast, and customized just for you!




Already a member?

Sign In Now »