Tenecteplase Appears Superior to Alteplase After Ischemic Stroke

Share this content:
Tenecteplase Appears Superior to Alteplase After Ischemic Stroke
Tenecteplase Appears Superior to Alteplase After Ischemic Stroke

THURSDAY, April 26, 2018 (HealthDay News) -- For patients with ischemic stroke, treatment with tenecteplase within 4.5 hours of symptom onset and before thrombectomy is associated with better outcomes than treatment with alteplase during the same timeframe, according to a study published in the April 26 issue the New England Journal of Medicine.

Bruce C.V. Campbell, Ph.D., from the Melbourne Brain Centre in Australia, and colleagues randomized 202 patients with ischemic stroke who had occlusion of the internal carotid, basilar, or middle cerebral artery, and who were eligible for thrombectomy, to receive tenecteplase (101 patients) or alteplase (101 patients) within 4.5 hours after symptom onset. Primary outcome was reperfusion of greater than 50 percent of the involved ischemic territory or an absence of retrievable thrombus at the time of the initial angiographic assessment.

The researchers found that the primary outcome occurred in 22 and 10 percent of those treated with tenecteplase and alteplase, respectively (incidence ratio, 2.2; 95 percent confidence interval, 1.1 to 4.4; P = 0.002 for non-inferiority; P = 0.03 for superiority). Better 90-day functional outcome was seen with tenecteplase versus alteplase (median modified Rankin scale score, 2 versus 3; common odds ratio, 1.7; 95 percent confidence interval, 1.0 to 2.8; P = 0.04). In each group, 1 percent of patients experienced symptomatic intracerebral hemorrhage.

"Tenecteplase before thrombectomy was associated with a higher incidence of reperfusion and better functional outcome than alteplase among patients with ischemic stroke treated within 4.5 hours after symptom onset," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »