Tau May Predict Neurological Outcome After Cardiac Arrest

This article originally appeared here.
Share this content:
Tau May Predict Neurological Outcome After Cardiac Arrest
Tau May Predict Neurological Outcome After Cardiac Arrest

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Serum tau is a promising novel biomarker for prediction of neurological outcome in patients with cardiac arrest, according to a study published online Oct. 5 in the Annals of Neurology.

Niklas Mattsson, M.D., Ph.D., from Lund University in Sweden, and colleagues measured the neuronal protein tau in serum at 24, 48, and 72 hours after cardiac arrest in 689 patients to test serum tau as a predictor of neurological outcome.

The researchers found that increased tau was associated with poor outcome at six months after cardiac arrest (median 38.5 ng/L in poor versus 1.5 ng/L in good outcome, for tau at 72 hours). Prediction of poor outcome was improved with tau compared with using clinical information. Tau cutoffs had low false positive rates for good outcome and retained high sensitivity for poor outcome. For example, at 72 hours, tau had a false positive rate of 2 percent with a sensitivity of 66 percent. Tau also had higher accuracy than serum neuron-specific enolase (NSE) and was significantly associated with overall survival during follow-up.

"[Serum tau] may be significantly better than serum NSE, which is recommended in guidelines and currently used in clinical practice in several countries to predict outcome after cardiac arrest," conclude the authors.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »