Tamoxifen, Raloxifene Linked to Improvements in MD in Mice

Share this content:
Tamoxifen, Raloxifene Linked to Improvements in MD in Mice
Tamoxifen, Raloxifene Linked to Improvements in MD in Mice

TUESDAY, March 20, 2018 (HealthDay News) -- Tamoxifen and raloxifene are associated with improvements in muscular dystrophy caused by mutations of the Fukutin-related protein (FKRP) gene in a mouse model, according to a study published in the April issue of The American Journal of Pathology.

Bo Wu, Ph.D., from the McColl-Lockwood Laboratory for Muscular Dystrophy Research in Charlotte, N.C., and colleagues examined the therapeutic values of tamoxifen and raloxifene in FKRPP448L mutant mice with severe dystrophic phenotype. Mice received the drugs for one year with daily gavage.

The researchers found that there was significant amelioration of disease progression with tamoxifen and raloxifene. Increase in grip force production, extended running time and distance in the treadmill test, and enhancement in cardiac and respiratory functions were identified as improvements. Diminished fibrosis and fiber degeneration were identified as significant reductions in muscle pathology. In addition, bone loss was significantly mitigated by tamoxifen and raloxifene. Severe adverse effects on male reproductive organs were seen with tamoxifen but not raloxifene.

"The results demonstrate that tamoxifen and raloxifene hold significant potential for treating FKRP-related muscular dystrophy and probably other muscular dystrophies," the authors write. "Sex-related differential effects of the drugs call for a careful consideration for the drug and dosage selection in male and female patient populations."

Abstract/Full Text (subscription or payment nay be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

'Aggressive Steps' Needed to Stop Adolescent Use of E-Cigarettes

'Aggressive Steps' Needed to Stop Adolescent Use of ...

U.S. Surgeon General issues a call to action for parents, teachers, and health professionals

Exercise Linked to Reduced Mortality for Patients With Cancer

Exercise Linked to Reduced Mortality for Patients With ...

Mortality rate lower for habitually active patients and for those who started exercising after diagnosis

Hospitalizations Up for Homeless From 2007 to 2013

Hospitalizations Up for Homeless From 2007 to 2013

Homeless individuals hospitalized more often for mental illness, substance use disorder

is free, fast, and customized just for you!




Already a member?

Sign In Now »