T2DM Initially Remits in Majority Who Undergo Gastric Bypass

Share this content:
T2DM Initially Remits in Majority Who Undergo Gastric Bypass
T2DM Initially Remits in Majority Who Undergo Gastric Bypass

THURSDAY, Feb. 7, 2019 (HealthDay News) -- Roux-en-Y gastric bypass (RYGB) is associated with high levels of type 2 diabetes remission at one year, although 27 percent relapse after five years, according to a study published online Feb. 6 in Diabetologia.

Lene R. Madsen, from Aarhus University Hospital in Denmark, and colleagues conducted a population-based study of 1,111 individuals with type 2 diabetes and obesity treated by RYGB from 2006 to 2015 and 1,074 matched individuals with type 2 diabetes who did not undergo surgery.

The researchers found that 74 percent of the RYGB cohort experienced diabetes remission at one-year follow-up; after five years, 27 percent had relapsed. Age >50 years, diabetes duration longer than five years, use of glucose-lowering drugs other than metformin, and baseline hemoglobin A1c >7.0 percent were predictors of nonremission. The RYGB cohort had a significantly lower risk for microvascular complications (hazard ratio, 0.53; 95 percent confidence interval, 0.38 to 0.73) and a statistically nonsignificant lower risk for macrovascular complications (hazard ratio, 0.76; 95 percent confidence interval, 0.49 to 1.18) compared with the nonsurgical cohort. At one year, diabetes remission versus nonremission correlated with a significantly reduced risk for microvascular complications (hazard ratio, 0.43; 95 percent confidence interval, 0.25 to 0.72) and a nonsignificantly reduced risk for macrovascular complications (hazard ratio, 0.76; 95 percent confidence interval, 0.40 to 1.45).

"RYGB does remit type 2 diabetes and is associated with a reduced risk of microvascular, and possibly macrovascular, complications," the authors write.

The study was partially funded by the Novo Nordisk Foundation.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Operative Treatment Seems Most Effective for Adult Lumbar Scoliosis

Operative Treatment Seems Most Effective for Adult Lumbar ...

Nonoperative tx advised if patient satisfied with spine-related health; surgery may improve outcomes

Intervention Can Reduce Orders for Inpatient Urine Cultures

Intervention Can Reduce Orders for Inpatient Urine Cultures

Intervention includes notifications to providers, changes to order sets, new urine culture reflex tests

Odds of Receiving Tx for CAD Up With Medicare Advantage

Odds of Receiving Tx for CAD Up With ...

However, no significant difference seen in intermediate outcomes for those enrolled in MA, FFS Medicare

is free, fast, and customized just for you!




Already a member?

Sign In Now »