Sustained Smoking Cessation May Delay, Prevent Seropositive RA

Share this content:
Sustained Smoking Cessation May Delay, Prevent Seropositive RA
Sustained Smoking Cessation May Delay, Prevent Seropositive RA

WEDNESDAY, Feb. 27, 2019 (HealthDay News) -- While smoking is a strong risk factor for seropositive rheumatoid arthritis (RA), sustained smoking cessation could delay or even prevent disease development, according to a study published online Feb. 21 in Arthritis Care & Research.

Xinyi Liu, from Brigham and Women's Hospital in Boston, and colleagues assessed smoking cessation and RA risk among participants in the Nurses' Health Study (NHS; 1976 to 2014) and the NHSII (1989 to 2015). Biennial questionnaires were used to ascertain smoking exposure, while self-reported RA was confirmed by medical record review.

The researchers found that among 230,732 women, there were 1,528 incident RA cases (63.4 percent seropositive). Current smoking increased risk for all RA (multivariable hazard ratio [HR], 1.47; 95 percent confidence interval, 1.27 to 1.72) and seropositive RA (HR, 1.67; 95 percent confidence interval, 1.38 to 2.01) but not seronegative RA (HR, 1.2; 95 percent confidence interval, 0.93 to 1.55) compared with never smoking. The risk for all RA increased with increasing smoking pack-years and seropositive RA. A decreased trend in risk was seen with increasing duration of smoking cessation for all RA and seropositive RA. Although those who quit ≥30 years ago had a hazard ratio of 0.63 for seropositive RA compared with recent quitters (less than five years), there was still a modestly elevated RA risk detectable 30 years after quitting smoking (all RA: HR, 1.25; seropositive RA: HR, 1.3 [both compared with never smoking]).

"Our study is one of the first to show that a behavior change of prolonged smoking cessation may actually delay or even prevent the onset of seropositive RA, suggesting lifestyle changes may modify risk for development of a systemic rheumatic disease," a coauthor said in a statement.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »