'SuperAgers' Have Less Whole-Brain Cortical Volume Loss

Share this content:
'SuperAgers' Have Less Whole-Brain Cortical Volume Loss
'SuperAgers' Have Less Whole-Brain Cortical Volume Loss

WEDNESDAY, April 5, 2017 (HealthDay News) -- Cognitively-average elderly adults have greater annual whole-brain cortical volume loss than adults age 80 years and older with episodic memory ability at least as good as that of average middle-age adults (SuperAgers), according to a research letter published in the April 4 issue of the Journal of the American Medical Association.

Amanda H. Cook, from Northwestern University in Chicago, and colleagues quantitated the rates of cortical volume change over 18 months in SuperAgers and cognitively-average elderly adults. Data were included for 24 SuperAgers and 12 cognitively-average elderly adults who had structural magnetic resonance imaging scans at two consecutive study visits about 18 months apart.

The researchers found that, compared with cognitively-average elderly adults, SuperAgers had significantly higher category fluency at visit one and episodic memory scores at both visits. Both groups had statistically significant mean annual percent whole-brain cortical volume loss (SuperAgers, 1.06 percent [95 percent confidence interval, 0.50 to 1.63 percent; P < 0.001]; cognitively-average elderly, 2.24 percent [95 percent confidence interval, 1.06 to 3.42 percent; P = 0.002]). Cognitively-average elderly had an annual percent change in whole-brain cortical volume loss that was significantly greater than that seen in SuperAgers (difference, 1.18 percent; 95 percent confidence interval, 0.08 to 2.28 percent; unadjusted P = 0.04; adjusted P = 0.02).

"Cognitively-average elderly adults demonstrated greater annual whole-brain cortical volume loss compared with SuperAgers," the authors write. "The possibility that SuperAgers were also constitutionally endowed with larger brains throughout life cannot be ruled out."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »