Subunit Vaccine Efficacious Against Herpes Zoster

This article originally appeared here.
Share this content:
Subunit Vaccine Efficacious Against Herpes Zoster
Subunit Vaccine Efficacious Against Herpes Zoster

WEDNESDAY, April 29, 2015 (HealthDay News) -- A subunit vaccine containing varicella-zoster virus glycoprotein E and the AS01B adjuvant system (HZ/su) is efficacious against herpes zoster infection in older adults, according to a study published online April 28 in the New England Journal of Medicine. The research was published to coincide with the European Congress of Clinical Microbiology and Infectious Diseases, held from April 25 to 28 in Copenhagen, Denmark.

Himal Lal, M.D., from GSK Vaccines in King of Prussia, Pa., and colleagues conducted a randomized, placebo-controlled phase 3 trial in 18 countries to examine the efficacy and safety of HZ/su in older adults who were separated according to age group (50 to 59, 60 to 69, and ≥70 years). A total of 15,411 participants were randomized to receive two intramuscular doses of the vaccine (7,698 participants) or placebo (7,713 participants) two months apart.

The researchers confirmed herpes zoster infection in six participants in the vaccine group and 210 in the placebo group during a mean follow-up of 3.2 years (incidence rate, 0.3 versus 9.1 per 1,000 person years). Vaccine efficacy was 97.2 percent overall, and varied from 96.6 to 97.9 percent for all age groups. The vaccine group had more frequent solicited injection-site and systemic reactions within seven days after vaccination. Grade 3 solicited or unsolicited symptoms were reported in 17.0 and 3.2 percent of vaccine and placebo recipients, respectively.

"The HZ/su vaccine significantly reduced the risk of herpes zoster in adults who were 50 years of age or older," the authors write. "Vaccine efficacy in adults who were 70 years of age or older was similar to that in the other two age groups."

The study was funded by GlaxoSmithKline Biologicals, which is developing HZ/su.

Abstract
Full Text
Editorial
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Salmonella Outbreak in 26 States Linked to Raw Turkey Products

<i>Salmonella</i> Outbreak in 26 States Linked to Raw ...

40 individuals have been hospitalized to date; no deaths have been reported

FDA Recalls Drugs Containing Active Ingredient Valsartan

FDA Recalls Drugs Containing Active Ingredient Valsartan

All lots of non-expired products that contain valsartan supplied by Zhejiang Huahai being recalled

Atopic Dermatitis Places Heavy Burden on Patients

Atopic Dermatitis Places Heavy Burden on Patients

Overall and mental health, life satisfaction all impacted, especially for moderate, severe disease

is free, fast, and customized just for you!




Already a member?

Sign In Now »