Sublingual Birch Pollen Preparation Improves Allergy

This article originally appeared here.
Share this content:
Sublingual Birch Pollen Preparation Improves Allergy
Sublingual Birch Pollen Preparation Improves Allergy

THURSDAY, Sept. 10, 2015 (HealthDay News) -- For adults with birch pollen-induced allergic rhinitis, a sublingual birch pollen preparation (SB) is associated with improvement in symptom scores versus placebo, according to a study published online Sept. 3 in Allergy.

Oliver Pfaar, M.D., from the Center for Rhinology and Allergology Wiesbaden in Germany, and colleagues conducted a combined tolerability and dose-finding study with SB involving 269 adults with birch pollen-induced allergic rhinitis. Participants were randomly allocated to placebo or to SB at concentrations of 3,333, 10,000, 20,000, or 40,000 AUN/mL. At baseline and after five months of treatment, the authors determined the differences in symptom scores following a titrated nasal provocation test.

The researchers found that symptom scores improved in all treatment groups after treatment versus baseline, with an additional stepwise improvement in the active groups versus placebo that was significant in high-dose groups (P = 0.008 and P < 0.001, respectively). A significant linear dose-response curve was observed for this primary end point: The higher the dose, the better the improvement. Compared with placebo, active treatment correlated with increased peak nasal inspiratory flow and serum immunoglobulin G levels. Improvements were highest in the 40,000 AUN/mL group. More adverse reactions were seen for all active doses versus placebo, which were primarily mild and well controlled.

"All active treatment groups showed better responses than placebo for both primary and secondary parameters," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry; Pharm-Olam International provided assistance in conducting the study. HAL Allergy B.V., sponsored the trial.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »