Statins May Raise Odds of T2DM in Those at High Risk

Share this content:
Statins May Raise Odds of T2DM in Those at High Risk
Statins May Raise Odds of T2DM in Those at High Risk

TUESDAY, Oct. 24, 2017 (HealthDay News) -- For populations at high-risk for diabetes, statin use is associated with increased risk of developing diabetes, according to a study published online Oct. 23 in BMJ Open Diabetes Research & Care.

Jill P. Crandall, M.D., from Albert Einstein College of Medicine in Bronx, New York, and colleagues assessed incident diabetes by annual 75 g oral glucose tolerance testing and semiannual fasting glucose among 3,234 participants enrolled in the Diabetes Prevention Program Outcomes Study, a long-term follow-up to a randomized clinical trial of interventions to prevent type 2 diabetes. Lipid profile was assessed annually, and statin use was assessed at baseline and semiannual visits; participants' physicians determined statin treatment.

The researchers found that the cumulative incidence of statin initiation before diabetes diagnosis was 33 to 37 percent among the randomized treatment groups at 10 years. Irrespective of treatment group, statin use was correlated with increased diabetes risk, with a pooled hazard ratio of 1.36 for incident diabetes. Adjustment for baseline diabetes risk factors and potential confounding variables related to indications for statin therapy did not materially affect risk.

"In this population at high risk for diabetes, we observed significantly higher rates of diabetes with statin therapy in all three treatment groups," the authors write. "The effect of statins to increase diabetes risk appears to extend to populations at high risk for diabetes."

Bristol-Myers Squibb and Parke-Davies provided funding and material support during the Diabetes Prevention Program; Merck-Sante provided medication, and LifeScan provided materials during the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study. Several pharmaceutical, health care, nutrition, and sports equipment companies donated materials, equipment, or medicines for concomitant conditions.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Study Provides Estimates of U.S. Prevalence of Type 1, 2 Diabetes

Study Provides Estimates of U.S. Prevalence of Type ...

Prevalence of type 1 diabetes 0.5 percent, type 2 diabetes 8.5 percent among U.S. adults

Black Individuals at Highest Risk of Legal Intervention Injury

Black Individuals at Highest Risk of Legal Intervention ...

Increase in rates of injuries from 2005 to 2009, followed by a drop to 2015, returning to ~2005 levels

Research Links Doctor Burnout to Patient Safety Incidents

Research Links Doctor Burnout to Patient Safety Incidents

Physician burnout linked to increased risk of patient safety incidents, reduced patient satisfaction

is free, fast, and customized just for you!




Already a member?

Sign In Now »