Sofosbuvir Improves Renal Safety in Patients With Chronic Hep C

Share this content:
Sofosbuvir Improves Renal Safety in Patients With Chronic Hep C
Sofosbuvir Improves Renal Safety in Patients With Chronic Hep C

FRIDAY, May 11, 2018 (HealthDay News) -- Sofosbuvir-based treatment appears to guarantee renal safety for patients with chronic hepatitis C virus over one year of follow-up, according to a study published online May 7 in the Journal of Clinical Pharmacy and Therapeutics.

Thalia Medeiros, from the Universidade Federal Fluminense in Niterói, Brazil, and colleagues evaluated renal biomarkers among 94 chronic hepatitis C patients treated with sofosbuvir therapy. Urine samples were collected at the end of therapy, after 12 weeks sustained virological response, and one year post-treatment.

The researchers found that 98.9 percent of patients reached sustained virological response. In patients with glomerular filtration rate (GFR) ≥45 mL/min/1.73 m² there was significant improvement in renal biomarkers, as indicated by a progressive increase in mean GFR values until one year. There was no evidence of tubular dysfunction. There was no change in renal biomarkers among patients with baseline GFR <45 mL/min/1.73 m².

"In a 'real-life experience' of a Brazilian center, sofosbuvir therapy appears to guarantee renal safety for patients with chronic hepatitis C followed until one year after treatment," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Cognitive Disability Most Prevalent Type in Young Adults

Cognitive Disability Most Prevalent Type in Young Adults

Disability-specific disparities prevalent in access to health care, especially for young, middle-aged adults

Declines in Life Expectancy in Many High-Income Countries

Declines in Life Expectancy in Many High-Income Countries

And increase in midlife death rates across racial and ethnic groups in the United States

Tobacco Content Still Common on U.K. Prime-Time Television

Tobacco Content Still Common on U.K. Prime-Time Television

Tobacco content occurred in 33 percent of all programs; 8 percent of all adverts, trailer breaks

is free, fast, and customized just for you!




Already a member?

Sign In Now »