Sleeve Gastrectomy Linked to Improved Glycemia in Mice

Share this content:
Sleeve Gastrectomy Linked to Improved Glycemia in Mice
Sleeve Gastrectomy Linked to Improved Glycemia in Mice

WEDNESDAY, Feb. 28, 2018 (HealthDay News) -- Sleeve gastrectomy (SG) is associated with an improvement in glycemia, via increased insulin sensitivity, according to a study published online Feb. 23 in Diabetes.

Samir Abu Gazala, M.D., from the Hebrew University-Hadassah Medical School in Jerusalem, Israel, and colleagues performed SG on obese and diabetic leptin receptor-deficient mice (db/db) to examine the molecular mechanisms underlying improved glycemic control following bariatric surgery.

The researchers found that, compared with sham-operated controls, mice weighed 5 percent less and displayed improved glycemia one week post-surgery; islets from SG mice exhibited reduced expression of diabetes markers. SG mice weighed more at one month post-surgery than preoperatively, but they remained near-euglycemic and exhibited reduced hepatic lipid droplets. Surgery, and not weight loss, was responsible for reduced glycemia following SG as indicated in pair-feeding of SG and sham db/db mice. Indistinguishable insulin secretion profiles were identified in islets of sham and SG mice, but SG caused an improvement in muscle and hepatic insulin sensitivity, which was accompanied by hepatic regulation of HNF4a and PPARα targets.

"We conclude that long-term weight loss following SG requires leptin signaling," the authors write. "Nevertheless, SG elicits a remarkable improvement in glycemia via insulin sensitization, independent of reduced feeding and weight loss."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »