Sleeve Gastrectomy Linked to Improved Glycemia in Mice

Share this content:
Sleeve Gastrectomy Linked to Improved Glycemia in Mice
Sleeve Gastrectomy Linked to Improved Glycemia in Mice

WEDNESDAY, Feb. 28, 2018 (HealthDay News) -- Sleeve gastrectomy (SG) is associated with an improvement in glycemia, via increased insulin sensitivity, according to a study published online Feb. 23 in Diabetes.

Samir Abu Gazala, M.D., from the Hebrew University-Hadassah Medical School in Jerusalem, Israel, and colleagues performed SG on obese and diabetic leptin receptor-deficient mice (db/db) to examine the molecular mechanisms underlying improved glycemic control following bariatric surgery.

The researchers found that, compared with sham-operated controls, mice weighed 5 percent less and displayed improved glycemia one week post-surgery; islets from SG mice exhibited reduced expression of diabetes markers. SG mice weighed more at one month post-surgery than preoperatively, but they remained near-euglycemic and exhibited reduced hepatic lipid droplets. Surgery, and not weight loss, was responsible for reduced glycemia following SG as indicated in pair-feeding of SG and sham db/db mice. Indistinguishable insulin secretion profiles were identified in islets of sham and SG mice, but SG caused an improvement in muscle and hepatic insulin sensitivity, which was accompanied by hepatic regulation of HNF4a and PPARα targets.

"We conclude that long-term weight loss following SG requires leptin signaling," the authors write. "Nevertheless, SG elicits a remarkable improvement in glycemia via insulin sensitization, independent of reduced feeding and weight loss."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Incident Contrast Sensitivity Common in Middle-Aged Adults

Incident Contrast Sensitivity Common in Middle-Aged Adults

Factors linked to elevated risk include cadmium level in highest quintile, older age, more plaque sites

Tafamidis Treats Transthyretin Amyloid Cardiomyopathy

Tafamidis Treats Transthyretin Amyloid Cardiomyopathy

Reduces all-cause mortality, cardiovascular-related hospitalizations compared with placebo

Scribes Improve Physician Workflow, Patient Interaction

Scribes Improve Physician Workflow, Patient Interaction

Scribes lower EHR documentation burden for doctors and increase time spent interacting with patients

is free, fast, and customized just for you!




Already a member?

Sign In Now »