Simple ECG May Help Distinguish MDD From Bipolar Depression

Share this content:
Simple ECG May Help Distinguish MDD From Bipolar Depression
Simple ECG May Help Distinguish MDD From Bipolar Depression

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Heart rate variability (HRV) and specific inflammatory biomarkers can differentiate major depressive disorder (MDD) from depression in bipolar disorder (BD), according to a study published online Oct. 5 in The World Journal of Biological Psychiatry.

Brandon Hage, M.D., from the Loyola University Chicago Stritch School of Medicine in Maywood, Ill., and colleagues quantified HRV and measured inflammatory biomarkers in 64 patients with MDD and 37 with BD.

The researchers found that, compared with BD subjects, MDD subjects had significantly higher baseline respiratory sinus arrhythmia (P = 0.05) and low-frequency (LF)-HRV (P < 0.01). BD subjects had significantly higher baseline levels of interleukin-10 (IL-10; P < 0.01) and monocyte chemoattractant protein-1 (P < 0.01) than MDD subjects. Baseline LF-HRV was significantly positively associated with baseline levels of IL-10 in the MDD group only (r = 0.47; P < 0.01).

"Reduced vagal tone and higher levels of inflammatory biomarkers may distinguish BD from MDD and reveal an underlying pathophysiology of depression involving autonomic nervous system dysfunction and chronic immune system dysregulation," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »