Simple ECG May Help Distinguish MDD From Bipolar Depression

Share this content:
Simple ECG May Help Distinguish MDD From Bipolar Depression
Simple ECG May Help Distinguish MDD From Bipolar Depression

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Heart rate variability (HRV) and specific inflammatory biomarkers can differentiate major depressive disorder (MDD) from depression in bipolar disorder (BD), according to a study published online Oct. 5 in The World Journal of Biological Psychiatry.

Brandon Hage, M.D., from the Loyola University Chicago Stritch School of Medicine in Maywood, Ill., and colleagues quantified HRV and measured inflammatory biomarkers in 64 patients with MDD and 37 with BD.

The researchers found that, compared with BD subjects, MDD subjects had significantly higher baseline respiratory sinus arrhythmia (P = 0.05) and low-frequency (LF)-HRV (P < 0.01). BD subjects had significantly higher baseline levels of interleukin-10 (IL-10; P < 0.01) and monocyte chemoattractant protein-1 (P < 0.01) than MDD subjects. Baseline LF-HRV was significantly positively associated with baseline levels of IL-10 in the MDD group only (r = 0.47; P < 0.01).

"Reduced vagal tone and higher levels of inflammatory biomarkers may distinguish BD from MDD and reveal an underlying pathophysiology of depression involving autonomic nervous system dysfunction and chronic immune system dysregulation," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »