Sickle Cell Trait May Affect Reliability of HbA1c Readings

Share this content:
Sickle Cell Trait May Affect Reliability of HbA1c Readings
Sickle Cell Trait May Affect Reliability of HbA1c Readings

TUESDAY, Feb. 7, 2017 (HealthDay News) -- Hemoglobin A1c (HbA1c) measurements may be less accurate in black people who have sickle cell trait (SCT), according to a study published online Feb. 7 in the Journal of the American Medical Association.

The research included 4,620 patients (average age, 52.3) -- 1,572 from the CARDIA study, and 3,048 from the Jackson Heart Study. Both groups were evaluated to determine the association between SCT and HbA1c for given levels of fasting or two-hour glucose levels.

When assessing only HbA1c, the researchers found that 29.2 percent of blacks with SCT were diagnosed with prediabetes versus 48.6 percent of blacks without SCT. The corresponding numbers for diabetes were 3.8 and 7.3 percent. In unadjusted generalized estimating equations analyses, for a given fasting glucose, HbA1c values were lower in those with versus those without SCT (5.72 and 6.01 percent, respectively).

"These findings suggest that HbA1c may systematically underestimate past glycemia in black patients with SCT and may require further evaluation," the authors conclude.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »