Sex Hormones, Inflammation Affect Asthma in Obese Women

This article originally appeared here.
Share this content:
Sex Hormones, Inflammation Affect Asthma in Obese Women
Sex Hormones, Inflammation Affect Asthma in Obese Women

TUESDAY, March 29, 2016 (HealthDay News) -- Sex hormones and systemic inflammation may be mediating the obese-asthma phenotype, according to a study published online March 23 in Allergy.

Hayley A. Scott, Ph.D., from the University of Newcastle in Australia, and colleagues assessed the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in 39 obese and 42 nonobese females and 24 obese and 25 nonobese males with asthma.

The researchers found that obese reproductive-age females had higher sputum neutrophils compared with nonobese reproductive-age females (P = 0.016), but there was no difference in sputum neutrophils in obese and nonobese males (P = 0.62) or older females (P = 0.087). Testosterone and OCP use were negative predictors of sputum neutrophils, while CRP and interleukin-6 were positive predictors of sputum neutrophils. In a multivariate model, BMI and age were not significant predictors. Reproductive-age females using OCP had significantly lower sputum neutrophils than those not using OCP.

"This study suggests that sex hormones and systemic inflammation may be mediating the obese-asthma phenotype," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Salmonella Outbreak in 26 States Linked to Raw Turkey Products

<i>Salmonella</i> Outbreak in 26 States Linked to Raw ...

40 individuals have been hospitalized to date; no deaths have been reported

FDA Recalls Drugs Containing Active Ingredient Valsartan

FDA Recalls Drugs Containing Active Ingredient Valsartan

All lots of non-expired products that contain valsartan supplied by Zhejiang Huahai being recalled

Atopic Dermatitis Places Heavy Burden on Patients

Atopic Dermatitis Places Heavy Burden on Patients

Overall and mental health, life satisfaction all impacted, especially for moderate, severe disease

is free, fast, and customized just for you!




Already a member?

Sign In Now »