Sequential Empagliflozin, Linagliptin Diabetes Tx Effective

Share this content:
Sequential Empagliflozin, Linagliptin Diabetes Tx Effective
Sequential Empagliflozin, Linagliptin Diabetes Tx Effective

WEDNESDAY, Jan. 4, 2017 (HealthDay News) -- After metformin failure, sequential treatment escalation with empagliflozin and linagliptin is an effective diabetes treatment option due to additive effects on postprandial glucose control, according to a study published online Dec. 23 in Diabetes, Obesity and Metabolism.

Thomas Forst, M.D., from Johannes Gutenberg University in Mainz, Germany, and colleagues conducted an open-label trial (treatment period [TP] 1) in which 44 patients with type 2 diabetes received 25 mg empagliflozin for one month. In TP 2, patients were randomized to a double-blind add-on therapy with linagliptin 5 mg or placebo for another month. A standardized liquid meal test and an intravenous glucose challenge were used to assess alpha- and beta-cell function.

The researchers found that in TP 1, empagliflozin reduced fasting and postprandial plasma glucose levels, correlating with a significant reduction in postprandial insulin levels and an improvement in the conversion rate of proinsulin. In TP 2, addition of linagliptin further improved postprandial glucose levels, most likely due to a marked reduction in postprandial glucagon concentrations. The insulin response to an intravenous glucose load improved in both TPs.

"After metformin failure, sequential treatment escalation with empagliflozin and linagliptin is an attractive treatment option due to additive effects on postprandial glucose control, most probably mediated by complementary effects on alpha- and beta-cell function," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Tap Water in Neti Pot Linked to Death From Brain-Eating Amoeba

Tap Water in Neti Pot Linked to Death ...

Amoeba entered the upper nasal cavity and then the bloodstream, eventually reaching the brain

HIT-Related Stress Linked to Burnout Among Physicians

HIT-Related Stress Linked to Burnout Among Physicians

Odds of burnout up with report of poor/marginal time for documentation, time spent on EHR at home

Risk Up for Later-Born Siblings of Children With ASD, ADHD

Risk Up for Later-Born Siblings of Children With ...

Odds of both ASD and ADHD increased for later-born siblings of children with either diagnosis

is free, fast, and customized just for you!




Already a member?

Sign In Now »