Robust Immune Responses for Herpes Zoster Subunit Vaccine

Share this content:
Robust Immune Responses for Herpes Zoster Subunit Vaccine
Robust Immune Responses for Herpes Zoster Subunit Vaccine

MONDAY, May 21, 2018 (HealthDay News) -- Recipients of the herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01B Adjuvant System, develop robust immune responses, according to a study published in the June 1 issue of The Journal of Infectious Diseases.

Anthony L. Cunningham, M.D., from the University of Sydney, and colleagues presented immunogenicity results from two trials involving patients aged 50 years or older and aged 70 years or older who received two doses of HZ/su or placebo two months apart. In subcohorts with 3,293 and 466 participants for humoral and cell-mediated immunogenicity, respectively, serum anti-gE antibodies and CD4 T-cells expressing two or more of four activation markers assessed after stimulation with gE-peptides were measured.

The researchers identified a humoral response in 97.8 and 2 percent of HZ/su and placebo recipients, respectively, after vaccination. At one and 36 months post-dose 2, geometric mean anti-gE antibody concentrations increased 39.1- and 8.3-fold, respectively, over baseline in HZ/su recipients. In 93.3 and 0 percent of HZ/su and placebo recipients, respectively, there was a gE-specific CD42+ T-cell response. In HZ/su recipients, median CD42+ T-cell frequencies increased 24.6- and 7.9-fold over baseline at one and 36 months, respectively; in all age groups, the frequency remained ≥5.6-fold above baseline at 36 months. In all age groups there was an increase in the proportion of CD4 T-cells expressing all four activation markers over time.

"Most HZ/su recipients developed robust immune responses persisting for three years following vaccination," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including GlaxoSmithKline Biologicals SA, which funded the study.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Warns About 'Miracle' Young Blood Infusion Treatments

FDA Warns About 'Miracle' Young Blood Infusion Treatments

Expensive 'fountain of youth' therapies are unproven, potentially harmful

CDC: Salmonella Cases Tied to Raw Turkey Products Now at 279

CDC: <i>Salmonella</i> Cases Tied to Raw Turkey Products ...

Cases reported in 41 states and the District of Columbia; 107 people have been hospitalized

Chronic Wasting Disease Found in Deer in 24 States

Chronic Wasting Disease Found in Deer in 24 ...

No evidence disease can spread to humans, but hunters should be careful around potentially infected animals

is free, fast, and customized just for you!




Already a member?

Sign In Now »