Rituximab + Lenalidomide Effective in Follicular Lymphoma

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Rituximab + Lenalidomide Effective in Follicular Lymphoma
Rituximab + Lenalidomide Effective in Follicular Lymphoma

TUESDAY, Sept. 11, 2018 (HealthDay News) -- Rituximab plus lenalidomide has similar efficacy to rituximab plus chemotherapy among patients with previously untreated follicular lymphoma, according to a study published in the Sept. 6 issue of the New England Journal of Medicine.

Franck Morschhauser, M.D., Ph.D., from the University of Lille in France, and colleagues conducted an international, randomized phase 3 trial to evaluate rituximab plus lenalidomide (513 patients) versus rituximab plus chemotherapy (one of three rituximab-based regimens; 517 patients) in patients with previously untreated follicular lymphoma. Both regimens were followed by rituximab maintenance therapy. Follow-up continued to 120 weeks.

The researchers found that the rate of confirmed or unconfirmed complete response at 120 weeks was similar in the two groups: 48 percent in the rituximab-lenalidomide group versus 53 percent in the rituximab-chemotherapy group (P = 0.13). The interim three-year rate of progression-free survival was also similar (77 versus 78 percent). In the rituximab-chemotherapy group, a higher percentage of patients had grade 3 or 4 neutropenia (50 versus 32 percent) and febrile neutropenia (7 versus 2 percent) of any grade. A higher percentage of patients in the rituximab-lenalidomide group had grade 3 or 4 cutaneous reactions (7 versus 1 percent).

"Among patients with previously untreated follicular lymphoma, efficacy results were similar with rituximab plus lenalidomide and rituximab plus chemotherapy," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Celgene, which manufactures lenalidomide and funded the study.

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