Risk-Stratified Breast Cancer Screening Ups Cost-Effectiveness

Share this content:
Risk-Stratified Breast Cancer Screening Ups Cost-Effectiveness
Risk-Stratified Breast Cancer Screening Ups Cost-Effectiveness

FRIDAY, July 6, 2018 (HealthDay News) -- Risk-stratified breast screening improves the cost-effectiveness of screening, according to a study published online July 5 in JAMA Oncology.

Nora Pashayan, M.D., Ph.D., from University College London, and colleagues used findings of the Independent U.K. Panel on Breast Cancer Screening and risk distribution based on polygenic risk profile to create a life-table model of a hypothetical cohort of 364,500 women in the United Kingdom aged 50 years with follow-up to 85 years. The modeled interventions were no screening, age-based screening, and risk-stratified screening.

The researchers found that the incremental cost of the program increased linearly compared with no screening as the risk threshold was lowered; no additional quality-adjusted life-years (QALYs) were gained below the 35th percentile risk threshold. The highest net monetary benefit was seen for the risk-stratified screening scenario with risk threshold at the 70th percentile, at a willingness to pay of $26,800 per QALY gained; the probability of being cost-effective was 72 percent. Risk-stratified screening at the 32nd versus the 70th percentile risk threshold would cost $26,888 versus $720,900 less, would result in 26.7 versus 71.4 percent fewer overdiagnoses, and would avert 2.9 versus 9.6 percent fewer breast cancer deaths relative to age-based screening.

"Not offering breast cancer screening to women at lower risk could improve the cost-effectiveness of the screening program, reduce overdiagnosis, and maintain the benefits of screening," the authors write.

Abstract/Full Text
Editorial

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Bayer Stops U.S. Sale of Essure Birth Control Implant

Bayer Stops U.S. Sale of Essure Birth Control ...

Problems with device include chronic pain and perforations of the uterus and fallopian tubes

C.S. Mott Poll Addresses Child Safety at Amusement Parks

C.S. Mott Poll Addresses Child Safety at Amusement ...

2016 saw U.S. emergency departments deal with 30,000 injuries linked to amusement parks, carnivals

Greening Vacant Land Improves Neighborhood Mental Health

Greening Vacant Land Improves Neighborhood Mental Health

Cleaning up vacant lots in resource-limited urban settings can aid residents' mental health

is free, fast, and customized just for you!




Already a member?

Sign In Now »