Risk of Febrile Seizures Up With Vaccine Combos

Share this content:
Risk of Febrile Seizures Up With Vaccine Combos
Risk of Febrile Seizures Up With Vaccine Combos

MONDAY, June 6, 2016 (HealthDay News) -- Concomitant administration of inactivated influenza vaccine (IIV3) and pneumococcal conjugate vaccine (PCV) or diphtheria-tetanus-acellular-pertussis (DTaP)-containing vaccine is associated with an increased risk of febrile seizures (FS), according to a study published online June 6 in Pediatrics.

Jonathan Duffy, M.D., M.P.H., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues examined the risk of FS at zero to one day after vaccination for all routinely recommended vaccinations among children aged 6 through 23 months. A population-based self-controlled risk interval analysis was used, with a control interval of 14 to 20 days after vaccination. The authors controlled for receipt of concomitant vaccines using multivariable regression.

The researchers observed an independent FS risk with PCV 7-valent only (incidence rate ratio [IRR], 1.98; 95 percent confidence interval [CI], 1.00 to 3.91). There was no independent risk for IIV3 (IRR, 0.46; 95 percent CI, 0.21 to 1.02); the risk was increased with administration of IIV3 together with PCV (IRR, 3.50; 95 percent CI, 1.13 to 10.85) or a DTaP-containing vaccine (IRR, 3.50; 95 percent CI, 1.52 to 8.07). Compared with administration on separate days, the maximum estimated absolute excess risk due to concomitant administration of IIV3, PCV, and DTaP-containing vaccines was 30 FS per 100,000 persons vaccinated.

"The administration of IIV3 on the same day as either PCV or a DTaP-containing vaccine was associated with a greater risk of FS than when IIV3 was given on a separate day," the authors write. "The absolute risk of post-vaccination FS with these vaccine combinations was small."

Two authors disclosed financial ties to the biopharmaceutical industry.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Tap Water in Neti Pot Linked to Death From Brain-Eating Amoeba

Tap Water in Neti Pot Linked to Death ...

Amoeba entered the upper nasal cavity and then the bloodstream, eventually reaching the brain

HIT-Related Stress Linked to Burnout Among Physicians

HIT-Related Stress Linked to Burnout Among Physicians

Odds of burnout up with report of poor/marginal time for documentation, time spent on EHR at home

Risk Up for Later-Born Siblings of Children With ASD, ADHD

Risk Up for Later-Born Siblings of Children With ...

Odds of both ASD and ADHD increased for later-born siblings of children with either diagnosis

is free, fast, and customized just for you!




Already a member?

Sign In Now »