Risk of Conversion to Multiple Sclerosis Down With Minocycline

Share this content:
Risk of Conversion to Multiple Sclerosis Down With Minocycline
Risk of Conversion to Multiple Sclerosis Down With Minocycline

THURSDAY, June 1, 2017 (HealthDay News) -- For patients with a first demyelinating event (clinically isolated syndrome), treatment with minocycline is associated with reduced risk of conversion to multiple sclerosis over six months, according to a study published in the June 1 issue of the New England Journal of Medicine.

Luanne M. Metz, M.D., from the Cumming School of Medicine and the Hotchkiss Brain Institute in Calgary, Canada, and colleagues randomized 142 participants who had had their first demyelinating symptoms within the previous 180 days to receive 100 mg minocycline (72 participants) or placebo (70 participants) until a diagnosis of multiple sclerosis was established or until 24 months after randomization.

The researchers found that the unadjusted risk of conversion to multiple sclerosis within six months after randomization was 61.0 and 33.4 percent in the placebo and minocycline groups, respectively (difference, 27.6 percent; 95 percent confidence interval, 11.4 to 43.9; P = 0.001). The difference in the risk of conversion to multiple sclerosis within six months after randomization was 18.5 percentage points, after adjustment for the number of enhancing lesions at baseline (95 percent confidence interval, 3.7 to 33.3; P = 0.01). At the 24-month secondary outcome time point, the unadjusted risk difference was not significant (P = 0.06).

"The risk of conversion from a clinically isolated syndrome to multiple sclerosis was significantly lower with minocycline than with placebo over six months but not over 24 months," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: More Than 400 Sickened by McDonald's Salads

CDC: More Than 400 Sickened by McDonald's Salads

Multistate outbreak of Cyclosporiasis linked to McDonald's Fresh Express Salad Mix

Jury Awards 289 Million in Case Linking Roundup to Man's Cancer

Jury Awards $289 Million in Case Linking Roundup ...

Case could set a precedent for other lawsuits against Monsanto, the manufacturer of Roundup

Prenatal Tdap Vaccination Not Linked to Autism Risk

Prenatal Tdap Vaccination Not Linked to Autism Risk

No increased risk of autism spectrum disorder in association with prenatal Tdap vaccination

is free, fast, and customized just for you!




Already a member?

Sign In Now »