Revising Pooled Cohort Equations Improves CVD Risk Prediction

Share this content:
Revising Pooled Cohort Equations Improves CVD Risk Prediction
Revising Pooled Cohort Equations Improves CVD Risk Prediction

MONDAY, June 4, 2018 (HealthDay News) -- Revising the 2013 pooled cohort equations (PCEs) can improve accuracy of cardiovascular disease (CVD) risk prediction, according to a study published online June 5 in the Annals of Internal Medicine.

In an effort to improve the clinical accuracy of CVD risk prediction, Steve Yadlowsky, from Stanford University in California, and colleagues conducted a population-based study involving 26,689 adults aged 40 to 79 years without prior CVD from six U.S. cohorts.

The researchers found that across risk groups, the 2013 PCEs for atherosclerotic CVD overestimated 10-year risk by an average of 20 percent. Misestimation of risk was especially prominent among black adults; 33 percent of eligible black persons (3.9 million) had extreme risk estimates. Among all race and sex subgroups, accuracy was improved by updating these equations. Based on the updated equations, about 11.8 million U.S. adults previously labeled as high-risk by the 2013 PCEs would be relabeled as lower-risk.

"Updating the 2013 PCEs with data from modern cohorts reduced the number of persons considered to be at high risk. Clinicians and patients should consider the potential benefits and harms of reducing the number of persons recommended aspirin, blood pressure, or statin therapy," the authors write. "Our findings also indicate that risk equations will generally become outdated over time and require routine updating."

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Educational phone calls with nurses promote shared decision making in care

Early PT Linked to Less Opioid Use in Musculoskeletal Pain

Early PT Linked to Less Opioid Use in ...

For opioid-naive patients, early physical therapy tied to less opioid use in shoulder, neck, knee, back pain

Emotional Stress of Holidays Can Trigger Heart Attacks

Emotional Stress of Holidays Can Trigger Heart Attacks

Higher risk seen on Christmas Eve, particularly in older adults with diabetes, heart disease

is free, fast, and customized just for you!




Already a member?

Sign In Now »