Review: Point-of-Care Biomarker May Help Cut Antibiotic Use

This article originally appeared here.
Share this content:
Review: Point-of-Care Biomarker May Help Cut Antibiotic Use
Review: Point-of-Care Biomarker May Help Cut Antibiotic Use

(HealthDay News) -- The point-of-care C-reactive protein biomarker test of infection can reduce antibiotic use, although it does not affect clinical recovery, according to a review published online Nov. 6 in The Cochrane Library.

Rune Aabenhus, M.D., from the University of Copenhagen in Denmark, and colleagues examined the benefits and harms of point-of-care biomarker tests of infection for guiding antibiotic treatment in patients presenting with symptoms of acute respiratory infections. Data were reviewed from six trials (three randomized controlled trials [RCTs] and three cluster-RCTs) involving 3,284 participants that assessed the only point-of-care biomarker of infection, C-reactive protein.

The researchers observed a reduction in the use of antibiotic treatments in the C-reactive protein versus the standard-of-care group. The pooled risk ratio was 0.78 (95 percent confidence interval, 0.66 to 0.92; I², 68 percent); however, due to a high level of heterogeneity and statistically significant test for subgroup differences between the RCTs and cluster-RCTs, the results of the meta-analysis should be interpreted with caution. There was no difference in clinical recovery for use of the C-reactive protein point-of-care test and standard care. One study showed an increase in hospitalizations in the C-reactive protein group.

"A more precise effect estimate is needed to assess the costs of the intervention and compare the use of a point-of-care biomarker to other antibiotic-saving strategies," the authors write.

One author disclosed financial ties to Brahms Diagnostica (now Thermo-Fischer).

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wildfire Smoke Causing Poor Air Quality in U.S. Pacific Northwest

Wildfire Smoke Causing Poor Air Quality in U.S. ...

Air pollution advisories, air quality alerts issued for Washington, Oregon

Odds of Death Up With Exposure to Pregabalin, Opioids

Odds of Death Up With Exposure to Pregabalin, ...

Dose-response association with highest odds of opioid-related death with high-dose pregabalin

NYU Becomes First Medical School to Cover All Tuition

NYU Becomes First Medical School to Cover All ...

Full-tuition scholarships, regardless of need, offered to all new and current medical students

is free, fast, and customized just for you!




Already a member?

Sign In Now »