Review Identifies Features of Congenital Zika Infection

Share this content:
Review Identifies Features of Congenital Zika Infection
Review Identifies Features of Congenital Zika Infection

THURSDAY, Nov. 3, 2016 (HealthDay News) -- A distinctive phenotype of congenital Zika syndrome has been described in a review published online Nov. 3 in JAMA Pediatrics.

Cynthia A. Moore, M.D., Ph.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues reviewed the most recent evidence of congenital anomalies occurring in fetuses or infants with presumed or laboratory-confirmed intrauterine Zika infection. Congenital anomalies were considered in the context of the presumed pathogenetic mechanism related to the neurotropic properties of the virus.

The researchers found that congenital Zika syndrome has a distinct pattern of structural anomalies and functional disabilities, which are secondary to damage to the central, and possibly peripheral, nervous system. Many components of the syndrome are shared with other congenital infections, but five factors are unique to congenital Zika infection: severe microcephaly with partially collapsed skull; thin cerebral cortices with subcortical calcifications; macular scarring and focal pigmentary retinal mottling; congenital contractures; and marked early hypertonia and symptoms of extrapyramidal involvement.

"Although the full spectrum of adverse reproductive outcomes caused by Zika virus infection is not yet determined, a distinctive phenotype -- the congenital Zika syndrome -- has emerged," the authors write. "Recognition of this phenotype by clinicians for infants and children can help ensure appropriate etiologic evaluation and comprehensive clinical investigation to define the range of anomalies in an affected infant as well as determine essential follow-up and ongoing care."

Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Tap Water in Neti Pot Linked to Death From Brain-Eating Amoeba

Tap Water in Neti Pot Linked to Death ...

Amoeba entered the upper nasal cavity and then the bloodstream, eventually reaching the brain

HIT-Related Stress Linked to Burnout Among Physicians

HIT-Related Stress Linked to Burnout Among Physicians

Odds of burnout up with report of poor/marginal time for documentation, time spent on EHR at home

Risk Up for Later-Born Siblings of Children With ASD, ADHD

Risk Up for Later-Born Siblings of Children With ...

Odds of both ASD and ADHD increased for later-born siblings of children with either diagnosis

is free, fast, and customized just for you!




Already a member?

Sign In Now »