Respiratory Microbiome May Influence Inflammation in CF

This article originally appeared here.
Share this content:
Respiratory Microbiome May Influence Inflammation in CF
Respiratory Microbiome May Influence Inflammation in CF

MONDAY, July 31, 2017 (HealthDay News) -- Reduced bacterial diversity in the upper and lower airways in infants with cystic fibrosis (CF) is associated with use of prophylactic antibiotics and younger age at sampling, while less diversity in lavage samples is associated with lower inflammation, according to a study published online July 14 in the Annals of the American Thoracic Society.

Jessica E. Pittman, M.D., from Washington University in St. Louis, and colleagues enrolled infants with CF in a prospective, observational study to examine the bacterial microbiota and inflammatory profiles of the respiratory tract. Thirty-two infants underwent bronchoalveolar lavage and oropharyngeal sampling. The authors measured bacterial diversity and density (load), and analyzed lavage samples for inflammatory markers in the epithelial lining fluid.

The researchers observed a strong correlation in Shannon diversity between upper and lower airway samples from a given subject, although the community compositions differed. Younger subjects and those receiving daily anti-staphylococcal antibiotic prophylaxis had lower microbial diversity. Reduced diversity in lavage samples correlated with lower interleukin-8 concentration and absolute neutrophil count.

"Our findings suggest modification of the respiratory microbiome in infants with CF may influence airway inflammation," the authors write.

One author disclosed financial ties to Eli Lilly.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves First Generic EpiPen

FDA Approves First Generic EpiPen

Approval will address both rising costs and shortages of epinephrine

Report Details Corneal Infection Tied to Sleeping in Contacts

Report Details Corneal Infection Tied to Sleeping in ...

Six patients reported sleeping in lenses on regular basis; most had vision loss, permanent damage

Honey May Protect Children Who Swallow Button Batteries

Honey May Protect Children Who Swallow Button Batteries

Honey and Carafate appear to rapidly protect against batteries' caustic effects

is free, fast, and customized just for you!




Already a member?

Sign In Now »