Researchers Explore Nanofibers to Target, Treat Atherosclerosis

Share this content:
Researchers Explore Nanofibers to Target, Treat Atherosclerosis
Researchers Explore Nanofibers to Target, Treat Atherosclerosis

FRIDAY, May 11, 2018 (HealthDay News) -- Self-assembling peptide amphiphile (PA) nanofibers, incorporating an 18 amino acid sequence that retains the cholesterol efflux actions of apolipoprotein-A1 (apoA1) and a liver X receptor (LXR) agonist can target and treat atherosclerosis, according to an experimental study presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2018, held from May 10 to 12 in San Francisco.

Neel A. Mansukhani, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues fed low density lipoprotein receptor knockout mice a high-fat diet for 14 weeks, and then administered bi-weekly injections of the nanofibers or control for eight weeks.

The researchers found that the targeted PA nanofiber (ApoA PA) and Apo-A-LXR PA nanofibers effectively targeted atherosclerotic plaque in the aortic root. The optimum concentration of nanofiber and optimum dose were 2 mg/mL and 6 mg/kg, respectively. ApoA PA nanofiber localized to the aortic root for about two to three days; by seven to 10 days, ApoA PA nanofiber was cleared. One-day post-injection, concentrations of ApoA PA in the aortic root were five-fold higher than in the lung, liver, and kidney. Compared with phosphate-buffered saline treated controls, male and female mice treated with ApoA-LXR PA had 11 and 9 percent plaque reduction, respectively, after eight weeks of treatment.

The results "demonstrate that a novel targeted nanofiber binds specifically to atherosclerotic lesions and reduces plaque burden after a short treatment duration," Mansukhani said in a statement.

Press Release
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »