Recommendations Issued for Myeloma-Tied Renal Impairment

This article originally appeared here.
Share this content:
Recommendations Issued for Myeloma-Tied Renal Impairment
Recommendations Issued for Myeloma-Tied Renal Impairment

TUESDAY, March 15, 2016 (HealthDay News) -- Recommendations have been developed for the diagnosis and management of multiple myeloma-related renal impairment; the guidelines were published online March 14 in the Journal of Clinical Oncology.

Meletios A. Dimopoulos, M.D., from the University of Athens in Greece, and colleagues reviewed published data through December 2015 and developed practical recommendations for the diagnosis and management of multiple myeloma-related renal impairment.

The researchers recommend that all patients with myeloma should have serum creatinine, estimated glomerular filtration rate, and electrolytes measurements, as well as free light chain, if available, at diagnosis and at disease assessment; they should also have urine electrophoresis of a sample from a 24-hour urine collection (grade A). High fluid intake is indicated with antimyeloma therapy for the management of renal impairment in patients with multiple myeloma (grade B). High-cutoff hemodialysis membranes combined with antimyeloma therapy should be considered (grade B). The cornerstone for management of renal impairment remains bortezomib-based regimens (grade A). In addition, thalidomide is effective (grade B) and lenalidomide is effective and safe, mainly for patients with mild to moderate renal impairment (grade B).

"Carfilzomib can be safely administered to patients with creatinine clearance >15 mL/min, whereas ixazomib in combination with lenalidomide and dexamethasone can be safely administered to patients with creatinine clearance >30 mL/min (grade A)," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »