Recombinant Influenza Vaccine Found to Be Safe in Children

Share this content:
Recombinant Influenza Vaccine Found to Be Safe in Children
Recombinant Influenza Vaccine Found to Be Safe in Children

MONDAY, April 2, 2018 (HealthDay News) -- The recombinant influenza vaccine (RIV4) is well tolerated in children aged 6 to 17 years, and it provides immunogenicity comparable to that of the inactivated vaccine, according to a study published online April 2 in Pediatrics.

Lisa M. Dunkle, M.D., from Protein Sciences Corp. in Meriden, Conn., and colleagues compared the safety and immunogenicity of the quadrivalent RIV4 with that of the inactivated influenza vaccine in 219 children and adolescents 6 to 17 years of age (159 9- to 17-year-olds and 60 6- to 8-year-olds). Participants were randomly assigned in a 1:1 ratio to receive RIV4 or inactivated vaccine.

The researchers found that both vaccines were well tolerated in both 6- to 8-year-olds and 9- to 17-year-olds. There were no vaccine-related adverse events in the six months of follow-up. There were comparable antibody responses to most antigens in both vaccines in the older subjects. However, low responses to the influenza B Victoria lineage in both vaccines made interpretation difficult. In younger children, immunogenicity was similar, but noninferiority comparisons could not be made due to the truncated sample size.

"Future confirmatory clinical efficacy trials may be used to support the recombinant influenza vaccine as an alternative for the pediatric age group of ≥6 years," the authors write.

The authors disclosed financial ties to Protein Sciences Corp., which makes Flublok Quadrivalent, and to other vaccine manufacturers.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Both Abstinence and High Alcohol Use Linked to Dementia

Both Abstinence and High Alcohol Use Linked to ...

Increased dementia risk for those with abstinence or with drinking >14 units alcohol/week in midlife

Intervention Cuts Risk for HIV in Young Transgender Women

Intervention Cuts Risk for HIV in Young Transgender ...

Intervention group had greater reduction in condomless sex acts versus standard of care group

Trauma Surgery Association IDs Steps to Curb Firearm Violence

Trauma Surgery Association IDs Steps to Curb Firearm ...

14 recommendations include actions to be taken by federal government, professional bodies

is free, fast, and customized just for you!




Already a member?

Sign In Now »