Prophylaxis Can Prevent HCV Infection in Kidney Recipients

Share this content:
Prophylaxis Can Prevent HCV Infection in Kidney Recipients
Prophylaxis Can Prevent HCV Infection in Kidney Recipients

TUESDAY, March 6, 2018 (HealthDay News) -- Direct-acting antiviral prophylaxis is safe and prevents chronic hepatitis C virus (HCV) infection after kidney transplantation from HCV-infected donors to noninfected recipients, according to a study published online March 6 in the Annals of Internal Medicine.

Christine M. Durand, M.D., from Johns Hopkins University in Baltimore, and colleagues assessed the tolerability and feasibility of using direct-acting antivirals (grazoprevir and elbasvir) as prophylaxis before and after kidney transplant from HCV-infected donors to non-HCV-infected recipients (HCV D+/R transplant). The study included 10 HCV D+/R kidney transplant candidates who were older than 50 years and had no available living kidney donors.

The researchers found that there were no treatment-related adverse events among the 10 HCV D+/R transplant recipients. Twelve weeks after treatment, no HCV RNA was detected in any recipient.

"If confirmed in larger studies, this strategy should markedly expand organ options and reduce mortality for kidney transplant candidates without HCV infection," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Merck Sharp & Dohme Corp., which partially funded the study.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Racial Disparities Seen Among Teens Undergoing Flu Vaccination

Racial Disparities Seen Among Teens Undergoing Flu Vaccination

Hispanics have higher odds of vaccination, blacks have lower odds compared with whites

T2DM Linked to Decline in Verbal Memory, Fluency in Older Adults

T2DM Linked to Decline in Verbal Memory, Fluency ...

Brain atrophy does not appear to mediate the diabetes-cognition relationship

Certain Sites of Brain Lesions in MS Tied to Bowel Incontinence

Certain Sites of Brain Lesions in MS Tied ...

Left hemisphere dominates sensory visceral integration, right tied to the autonomic function

is free, fast, and customized just for you!




Already a member?

Sign In Now »