Preserved Neurogenesis in Hippocampus of Healthy Seniors

Share this content:
Preserved Neurogenesis in Hippocampus of Healthy Seniors
Preserved Neurogenesis in Hippocampus of Healthy Seniors

THURSDAY, April 5, 2018 (HealthDay News) -- Healthy older subjects display preserved neurogenesis, according to a study published in the April 5 issue of Cell Stem Cell.

Noting that aging humans are thought to exhibit waning neurogenesis and exercise-induced angiogenesis, with a resulting volumetric decline in the neurogenic hippocampal dentate gyrus (DG) region, Maura Boldrini, M.D., Ph.D., from Columbia University in New York City, and colleagues examined whole-autopsy hippocampi from healthy humans aged 14 to 79 years.

The researchers found that across ages, there were similar numbers of intermediate neural progenitors and thousands of immature neurons in the DG, equivalent numbers of glia and mature granule neurons, and similar DG volume. Older individuals had less angiogenesis and neuroplasticity, and also had a smaller quiescent progenitor pool in the anterior-mid DG; there were no changes in posterior DG in older adults.

"Healthy older subjects without cognitive impairment, neuropsychiatric disease, or treatment display preserved neurogenesis," the authors write. "It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive function throughout life and that declines may be linked to compromised cognitive-emotional resilience."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Access to In-Home Support Soon to Be Available for Seniors

Access to In-Home Support Soon to Be Available ...

Under Medicare Advantage, a health-related reason will be needed to qualify; costs will vary

USPSTF Recommends Screening Adults for Unhealthy Alcohol Use

USPSTF Recommends Screening Adults for Unhealthy Alcohol Use

Recommendation applies to all adults, including pregnant women; insufficient evidence for teens

AHA: Icosapent Ethyl Cuts CV Risk From Elevated Triglycerides

AHA: Icosapent Ethyl Cuts CV Risk From Elevated ...

Ischemic events reduced among patients with elevated triglycerides despite taking statins

is free, fast, and customized just for you!




Already a member?

Sign In Now »