Prenatal Valproate Exposure May Impact School Performance

Share this content:
Prenatal Valproate Exposure May Impact School Performance
Prenatal Valproate Exposure May Impact School Performance

WEDNESDAY, Feb. 21, 2018 (HealthDay News) -- School performance is significantly lower for children with prenatal exposure to valproate, according to a study published online Feb. 19 in JAMA Neurology.

Lars Skou Elkjaer, M.D., from Aarhus University in Denmark, and colleagues conducted a population-based cohort study to examine the correlation between long-term school performance and prenatal exposure to valproate and other antiepileptic drugs (AEDs). Data were included for 479,027 children born alive in Denmark between 1997 and 2006 who participated in national academic tests.

The researchers found that children exposed to valproate scored worse on the sixth-grade Danish tests (adjusted difference, −0.27 standard deviation [SD]) and sixth-grade mathematics tests (adjusted difference, − 0.33 SD) compared with unexposed and lamotrigine-exposed children (adjusted difference, −0.33 SD). Clonazepam-exposed children scored worse in the sixth-grade Danish tests (adjusted difference, −0.07 SD). Compared with unexposed children, carbamazepine, lamotrigine, phenobarbital, and oxcarbazepine exposure were not associated with poor school performance.

"Maternal use of valproate was associated with a significant decrease in school performance in offspring compared with children unexposed to AEDs and children exposed to lamotrigine," the authors write. "Findings of this study further caution against the use of valproate among women of childbearing potential."

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text
Editorial

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Critics Demand Stop to 'Guinea Pig' Sepsis Clinical Trial

Critics Demand Stop to 'Guinea Pig' Sepsis Clinical ...

Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis

Education Can Up Emotional Intelligence in Residents

Education Can Up Emotional Intelligence in Residents

Increase in total EI median scores, stress management composite score after intervention

Cancer-Related Gene Variations Frequently Reclassified

Cancer-Related Gene Variations Frequently Reclassified

24.9 percent of variants of uncertain significance were reclassified at a single commercial laboratory

is free, fast, and customized just for you!




Already a member?

Sign In Now »