PPD Skin Test Enhances Bacillus Calmette-Guérin Tx in Bladder CA

Share this content:
PPD Skin Test Enhances Bacillus Calmette-Guérin Tx in Bladder CA
PPD Skin Test Enhances Bacillus Calmette-Guérin Tx in Bladder CA

WEDNESDAY, May 16, 2018 (HealthDay News) -- For patients with non-muscle invasive bladder cancer, undergoing the purified protein derivative skin test prior to bacillus Calmette-Guérin therapy may have therapeutic impact, according to a study published in the June issue of The Journal of Urology.

Naoya Niwa, M.D., from the Keio University School of Medicine in Tokyo, and colleagues treated 498 patients with non-muscle invasive bladder cancer with adjuvant bacillus Calmette-Guérin; 320 of the patients underwent the purified protein derivative skin test one to two weeks before therapy.

The researchers found that the mean ± standard deviation five-year recurrence-free survival rate was 66.6 ± 2.8 percent and 59.1 ± 4.1 percent for patients who did and did not undergo the purified protein derivative skin test, respectively (P = 0.048). There were no significant differences between the groups in progression-free survival. Significant independent associations with tumor recurrence were seen for a history of recurrence, multiple tumors, the bacillus Calmette-Guérin Connaught strain, seven or more bacillus Calmette-Guérin instillations, and undergoing the purified protein derivative skin test. Overall, 24.1 and 15.2 percent of patients who did and did not undergo the test, respectively, had major bacillus Calmette-Guérin-related side effects (P = 0.02).

"Combination therapy with bacillus Calmette-Guérin using the purified protein derivative skin test may improve the oncologic outcomes of that therapy," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

8 More U.S. Communities to Be Assessed for PFAS Toxin Exposure

8 More U.S. Communities to Be Assessed for ...

Assessments will lay groundwork for future study of the health effects of perfluoroalkyl, polyfluoroalkyl

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

Proposed rule will help consumers better understand what the sunscreens they are buying can actually do

U.S. Agencies Probing Johnson  Johnson Over Asbestos in Talc

U.S. Agencies Probing Johnson & Johnson Over Asbestos ...

Company has faced lawsuits linking its body powders with ovarian cancer or mesothelioma

is free, fast, and customized just for you!




Already a member?

Sign In Now »