Post-Op Mortality Low Among HIV Patients Prescribed ART

This article originally appeared here.
Share this content:
Post-Op Mortality Low Among HIV Patients Prescribed ART
Post-Op Mortality Low Among HIV Patients Prescribed ART

(HealthDay News) -- Patients with HIV infection receiving antiretroviral therapy (ART) have increased 30-day postoperative mortality versus uninfected patients, although absolute incidence is low, according to a study published online Feb. 25 in JAMA Surgery.

Joseph T. King Jr., M.D., from the Veterans Affairs Connecticut Healthcare System in West Haven, and colleagues compared 30-day postoperative mortality in patients with HIV infection receiving ART with rates in uninfected individuals. Data from the U.S. Veterans Health Administration Healthcare System were obtained for Oct. 1, 1996, to Sept. 30, 2010, for 1,641 patients with HIV infection receiving combination ART and undergoing inpatient surgery and for 3,282 procedure-matched uninfected controls.

The researchers found that 30-day postoperative mortality was higher for patients with HIV infection versus uninfected patients (3.4 versus 1.6 percent; incidence rate ratio [IRR], 2.11; P < 0.001). There was an inverse association for CD4 cell count with mortality; HIV-1 RNA provided no additional information. Patients with HIV infection had increased mortality compared with uninfected patients at all CD4 cell count strata, after adjustment. Strong associations were also seen for hypoalbuminemia (IRR, 4.35) and age in decades (IRR, 1.47) with mortality.

"Current postoperative mortality rates among individuals with HIV infection who are receiving ART are low and are influenced as much by hypoalbuminemia and age as by CD4 cell status," the authors write. "Human immunodeficiency virus infection and CD4 cell count are only two of many factors associated with surgical outcomes that should be incorporated into surgical decision-making."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Actigraphy May Overestimate Sleep in ICU Setting

Actigraphy May Overestimate Sleep in ICU Setting

Wide ranges of sleep quality and quantity with use of actigraphy among critically ill patients in ICU

Mortality for Unintentional Drug Poisonings Up Since 1979

Mortality for Unintentional Drug Poisonings Up Since 1979

Trajectory of overall mortality rate smooth; no exponential trajectories in rates for individual drugs

Most Breast Cancer Diagnoses Given Over the Phone

Most Breast Cancer Diagnoses Given Over the Phone

This represents a reversal, with in-person diagnoses more common before 2006

is free, fast, and customized just for you!




Already a member?

Sign In Now »