Possible Link Found Between Poor Diet and Back Injuries

This article originally appeared here.
Share this content:
Possible Link Found Between Poor Diet and Back Injuries
Possible Link Found Between Poor Diet and Back Injuries

TUESDAY, Feb. 6, 2018 (HealthDay News) -- A high advanced glycation end product (H-AGE) diet is associated with decreased vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice, according to a study published recently in the Journal of Bone and Mineral Research.

Svenja Illien-Jünger, Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined whether high dietary AGE ingestion would diminish vertebral structure and function in a sex- and age-dependent manner. Female and male mice were fed low-AGE (L-AGE) or H-AGE diets for six and 18 months, and bone structure and function were measured.

The researchers observed an increase in AGE levels in serum and cortical vertebrae for 6-month-old H-AGE female mice, while for all animals, blood glucose and body weight remained normal. Six-month-old female mice had inferior vertebral trabecular structure with decreased bone mineral density (BMD) and bone volume fraction when fed an H-AGE diet. Six-month-old H-AGE females had functional deterioration with reduced shear and compression moduli, and maximum load to failure. H-AGE of both sexes had small but significant decreases in cortical BMD and thickness at 18 months, yet functional biomechanical behaviors were not distinguishable from other aging changes.

"We conclude that an H-AGE diet, without diabetic or overweight conditions, diminished vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice in a manner suggesting accelerated bone aging," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Dozens of Medical Groups Join Forces to Improve Diagnoses

Dozens of Medical Groups Join Forces to Improve ...

Diagnostic error is the most common cause of medical errors that patients report

HbA1c Variability Is a Strong Predictor of Mortality in T2DM

HbA1c Variability Is a Strong Predictor of Mortality ...

HbA1c variability is a powerful, independent measure, regardless of how it is measured

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Actual probability of death for patients on liver transplant wait list underestimated by up to 17%

is free, fast, and customized just for you!




Already a member?

Sign In Now »