Platelet Counts Rise With Viral Response to Hep C Therapy

This article originally appeared here.
Share this content:
Platelet Counts Rise With Viral Response to Hep C Therapy
Platelet Counts Rise With Viral Response to Hep C Therapy

TUESDAY, Dec. 15, 2015 (HealthDay News) -- Platelet counts rise among patients with chronic hepatitis C virus (HCV) infection who experience a sustained virological response (SVR) to antiviral therapy, according to research published online Dec. 8 in the Journal of Gastroenterology and Hepatology.

Adriaan J. van der Meer, M.D., Ph.D., of the Erasmus MC University Medical Center in Rotterdam, Netherlands, and colleagues conducted a retrospective cohort study to assess changes in platelet counts and spleen size following antiviral therapy for chronic HCV infection in 464 patients with advanced fibrosis.

The researchers found that 353 patients (76 percent) had cirrhosis and 187 patients (40 percent) achieved SVR. Median platelet count increased by 35 × 109/L (P < 0.001) for patients with SVR, and decreased by 17 × 109/L (P < 0.001) for patients without SVR. In a subgroup of 209 patients, median decrease in spleen size was 1.0 cm for patients with SVR compared and 0.6 cm in those without SVR (P < 0.001). A significant correlation was observed between changes in spleen size and platelet count (P < 0.001).

"Among chronic HCV-infected patients with advanced hepatic fibrosis, the platelet counts improved following SVR, and the change in platelets correlated with the change in spleen size following antiviral therapy," the authors write.

Several authors disclosed financial ties to the pharmaceutical and biomedical industries.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Zika, West Nile Cases Reported in Alabama

Zika, West Nile Cases Reported in Alabama

State health officials note that Zika hasn't been transmitted locally

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Increased suicide risk with one, two, and three or more medical contacts for traumatic brain injury

Triple Combo Blood Pressure Pill Can Improve BP Control

Triple Combo Blood Pressure Pill Can Improve BP ...

Proportion achieving target BP increased with use of triple combo pill versus usual care at six months

is free, fast, and customized just for you!




Already a member?

Sign In Now »