Physical Function Tied to Clinical, Subclinical Neurological Disease

Share this content:
Physical Function Tied to Clinical, Subclinical Neurological Disease
Physical Function Tied to Clinical, Subclinical Neurological Disease

MONDAY, Aug. 15, 2016 (HealthDay News) -- Physical function is associated with clinical and subclinical brain disease, according to a study published online Aug. 8 in the Journal of Alzheimer's Disease.

Erica C. Camargo, M.D., Ph.D., from Boston University, and colleagues examined the correlation of fast-paced walking speed and handgrip strength with the risk of dementia, Alzheimer's disease (AD), and stroke in a middle-aged community sample. A total of 2,176 participants from the Framingham Offspring study had physical function, brain magnetic resonance imaging, and cognitive evaluations from 1999 to 2005; they were followed until 11 years later for incident dementia, AD, and stroke.

The researchers found that slow walking and weak handgrip correlated with more than a 2.5-fold increase in the risk for AD. In persons aged 65 years and older, weaker handgrip was also associated with increased risk of incident stroke (hazard ratio, 1.74). There were correlations seen for both measures with lower total brain volume and poorer performance on visual memory, language, executive function, and visuoperceptual function tests. There were also correlations noted for slower gait with poorer verbal memory, and for weaker handgrip with poorer abstraction.

"Tests of walking speed and handgrip strength may serve as clinical markers of brain structure and function and may improve dementia risk prediction," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

More U.S. Teens Are Vaping, but Use of Opioids, Alcohol Falling

More U.S. Teens Are Vaping, but Use of ...

About 37 percent of 12th graders said they had vaped within the previous 12 months

Type 2 Diabetes Risk Lower in Women With Active Migraine

Type 2 Diabetes Risk Lower in Women With ...

Prevalence of active migraine decreased linearly in the 24 years prior to diabetes diagnosis

Buprenorphine-Naloxone Cost-Effective for Opioid Use Disorder

Buprenorphine-Naloxone Cost-Effective for Opioid Use Disorder

Treatment costs less than extended-release naltrexone without negative impact on outcomes

is free, fast, and customized just for you!




Already a member?

Sign In Now »