Peripheral Neuropathy Common in Childhood Cancer Survivors

Share this content:
Peripheral Neuropathy Common in Childhood Cancer Survivors
Peripheral Neuropathy Common in Childhood Cancer Survivors

TUESDAY, May 15, 2018 (HealthDay News) -- Childhood cancer survivors frequently have clinical abnormalities attributable to peripheral neuropathy, according to a study published online May 14 in JAMA Neurology.

Tejaswi Kandula, M.B.B.S., from the University of New South Wales in Sidney, and colleagues recruited cancer survivors who were treated with chemotherapy for extracranial malignancy before age 17 years and compared them with healthy age-matched controls. One hundred sixty-nine patients met the inclusion criteria; 121 childhood cancer survivors underwent neurotoxicity assessments at a median of 8.5 years after completion of treatment and were included in the analyses.

The researchers found that the main neurotoxic agents were vinca alkaloids and platinum compounds. Clinical abnormalities consistent with peripheral neuropathy were common and were observed in about half (50.5 percent) of those treated with neurotoxic chemotherapy (mean Total Neuropathy Score increase, 2.1); these abnormalities correlated with lower limb predominant sensory axonal neuropathy (mean amplitude reduction, 5.8 µV). There were functional deficits in manual dexterity, distal sensation, and balance. An association was seen for patient-reported outcomes demonstrating reduction in global quality of life and physical functioning with the Total Neuropathy Score. Long-term neurotoxicity was more frequently seen with cisplatin than with vinca alkaloids.

"Clinical abnormalities attributable to peripheral neuropathy were common in childhood cancer survivors and persisted long term, with concurrent deficits in patient-reported outcomes," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

8 More U.S. Communities to Be Assessed for PFAS Toxin Exposure

8 More U.S. Communities to Be Assessed for ...

Assessments will lay groundwork for future study of the health effects of perfluoroalkyl, polyfluoroalkyl

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

Proposed rule will help consumers better understand what the sunscreens they are buying can actually do

U.S. Agencies Probing Johnson  Johnson Over Asbestos in Talc

U.S. Agencies Probing Johnson & Johnson Over Asbestos ...

Company has faced lawsuits linking its body powders with ovarian cancer or mesothelioma

is free, fast, and customized just for you!




Already a member?

Sign In Now »