Perioperative Aspirin May Benefit Patients With Prior PCI

Share this content:
Perioperative Aspirin May Benefit Patients With Prior PCI
Perioperative Aspirin May Benefit Patients With Prior PCI

TUESDAY, Nov. 14, 2017 (HealthDay News) -- For patients with prior percutaneous coronary intervention (PCI), perioperative aspirin seems to be beneficial, according to a study published online Nov. 13 in the Annals of Internal Medicine.

Michelle M. Graham, M.D., from the University of Alberta in Canada, and colleagues performed a subgroup analysis of a multicenter trial to assess data for adults age ≥45 years who had or were at risk for atherosclerotic disease and were undergoing noncardiac surgery; 4,998 patients in the overall trial and 234 participants in the subgroup analysis received aspirin therapy, while 5,012 patients in the overall trial and 236 in the subgroup analysis received placebo initiated within four hours before surgery.

The researchers found that aspirin reduced the risk of the 30-day primary outcome of death or nonfatal myocardial infarction (absolute risk reduction, 5.5 percent; 95 percent confidence interval [CI], 0.4 to 10.5 percent; hazard ratio [HR], 0.5; 95 percent CI, 0.25 to 0.95 [P for interaction = 0.036]) and the risk of myocardial infarction (absolute risk reduction, 5.9 percent; 95 percent CI, 1 to 10.8 percent; HR, 0.44; 95 percent CI, 0.22 to 0.87 [P for interaction = 0.021]) in patients with prior PCI. In addition, the effect on the composite of major and life-threatening bleeding in patients with prior PCI was uncertain (absolute risk increase, 1.3 percent; 95 percent CI, −2.6 to 5.2 percent). Aspirin was correlated with increased risk for major bleeding in the overall population (absolute risk increase, 0.8 percent; 95 percent CI, 0.1 to 1.6 percent; HR, 1.22; 95 percent CI, 1.01 to 1.48 [P for interaction = 0.5]).

"Perioperative aspirin may be more likely to benefit rather than harm patients with prior PCI," the authors write.

Several authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

'Aggressive Steps' Needed to Stop Adolescent Use of E-Cigarettes

'Aggressive Steps' Needed to Stop Adolescent Use of ...

U.S. Surgeon General issues a call to action for parents, teachers, and health professionals

Exercise Linked to Reduced Mortality for Patients With Cancer

Exercise Linked to Reduced Mortality for Patients With ...

Mortality rate lower for habitually active patients and for those who started exercising after diagnosis

Hospitalizations Up for Homeless From 2007 to 2013

Hospitalizations Up for Homeless From 2007 to 2013

Homeless individuals hospitalized more often for mental illness, substance use disorder

is free, fast, and customized just for you!




Already a member?

Sign In Now »